86347-15-1

86347-15-1 structure

Name: Medetomidine HCl
Chemical Name: medetomidine hydrochloride
CAS Number: 86347-15-1
Molecular Formula: C₁₃H₁₇ClN₂
Molecular Weight: 236.740
Catalog: Biochemical Inhibitor Neuronal Signaling Adrenergic Receptor Agonist
Create Date: 2018-07-21 16:26:10
Modify Date: 2024-01-02 10:54:55
Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

Name	medetomidine hydrochloride
Synonyms	4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1) 1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) (±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) medetomidine HCl UNII:BH210P244U 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride Medetomidine (hydrochloride)

Description	Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39. [2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71. [3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

HS Code	2942000000

1021949-47-2

~89%

86347-15-1

Literature: "Joint Stock Company Grindeks" Patent: EP1918282 A1, 2008 ; Location in patent: Page/Page column 6 ;

86347-14-0

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Literature: WO2009/53709 A1, ; Page/Page column 13; 15-16 ;

576-23-8

86347-15-1

Literature: WO2013/14428 A1, ;

1421259-20-2

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Literature: WO2013/14428 A1, ;

1421259-22-4

86347-15-1

Literature: WO2013/14428 A1, ;

HS Code	2942000000