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86347-15-1

86347-15-1结构式

中文名	盐酸美托咪啶
英文名	medetomidine hydrochloride
中文别名	(R)-4-[1-(2,3-二甲基苯基)乙基]-1H-咪唑盐酸盐 5-[1-(2,3-二甲基苯基)乙基]-1H-咪唑盐酸盐环丙氨嗪盐酸美托咪定
英文别名	4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1) 1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) (±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) medetomidine HCl UNII:BH210P244U 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride Medetomidine (hydrochloride)

描述	Medetomidine(Domtor)盐酸盐是α2肾上腺素受体激动剂,对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体研究领域 >> 神经疾病
参考文献	[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39. [2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71. [3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

海关编码	2942000000

1021949-47-2

~89%

86347-15-1

文献："Joint Stock Company Grindeks" Patent: EP1918282 A1, 2008 ; Location in patent: Page/Page column 6 ;

86347-14-0

86347-15-1

文献：WO2009/53709 A1, ; Page/Page column 13; 15-16 ;

576-23-8

86347-15-1

文献：WO2013/14428 A1, ;

1421259-20-2

86347-15-1

文献：WO2013/14428 A1, ;

1421259-22-4

86347-15-1

文献：WO2013/14428 A1, ;

海关编码	2942000000