Medetomidine HCl

Modify Date: 2025-08-23 09:40:39

Medetomidine HCl Structure
Medetomidine HCl structure
Common Name Medetomidine HCl
CAS Number 86347-15-1 Molecular Weight 236.740
Density N/A Boiling Point 381.9ºC at 760 mmHg
Molecular Formula C13H17ClN2 Melting Point 164-166°C
MSDS N/A Flash Point 191.3ºC

 Use of Medetomidine HCl


Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

 Names

Name medetomidine hydrochloride
Synonym More Synonyms

 Medetomidine HCl Biological Activity

Description Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Related Catalog
References

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

 Chemical & Physical Properties

Boiling Point 381.9ºC at 760 mmHg
Melting Point 164-166°C
Molecular Formula C13H17ClN2
Molecular Weight 236.740
Flash Point 191.3ºC
Exact Mass 236.108032
PSA 28.68000
LogP 3.98030
Storage condition Refrigerator

 Safety Information

HS Code 2942000000

 Synthetic Route

~89%

Medetomidine HCl Structure

Medetomidine HCl

CAS#:86347-15-1

Literature: "Joint Stock Company Grindeks" Patent: EP1918282 A1, 2008 ; Location in patent: Page/Page column 6 ;

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Medetomidine HCl Structure

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2009/53709 A1, ; Page/Page column 13; 15-16 ;

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Medetomidine HCl Structure

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

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Medetomidine HCl Structure

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

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Medetomidine HCl Structure

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

 Customs

HS Code 2942000000

 Synonyms

4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
medetomidine HCl
UNII:BH210P244U
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride
Medetomidine (hydrochloride)
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