Medetomidine HCl

Modify Date: 2024-01-02 10:54:55

Medetomidine HCl structure	Common Name	Medetomidine HCl
	CAS Number	86347-15-1	Molecular Weight	236.740
	Density	N/A	Boiling Point	381.9ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₇ClN₂	Melting Point	164-166°C
	MSDS	N/A	Flash Point	191.3ºC

Use of Medetomidine HCl

Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

Name	medetomidine hydrochloride
Synonym	More Synonyms

Description	Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39. [2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71. [3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

References

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

Boiling Point	381.9ºC at 760 mmHg
Melting Point	164-166°C
Molecular Formula	C₁₃H₁₇ClN₂
Molecular Weight	236.740
Flash Point	191.3ºC
Exact Mass	236.108032
PSA	28.68000
LogP	3.98030
Storage condition	Refrigerator

HS Code	2942000000

5-[1-(2,3-Dimet...

CAS#:1021949-47-2

~89%

Medetomidine HCl

CAS#:86347-15-1

Literature: "Joint Stock Company Grindeks" Patent: EP1918282 A1, 2008 ; Location in patent: Page/Page column 6 ;

Medetomidine

CAS#:86347-14-0

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2009/53709 A1, ; Page/Page column 13; 15-16 ;

2,3-Dimethylbro...

CAS#:576-23-8

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

3-(2,3-dimethyl...

CAS#:1421259-20-2

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

N/A

CAS#:1421259-22-4

Medetomidine HCl

CAS#:86347-15-1

Literature: WO2013/14428 A1, ;

Precursor 3
CAS#:1021949-47-2 5-[1-(2,3-Dimet... CAS#:86347-14-0 Medetomidine CAS#:576-23-8 2,3-Dimethylbro...
DownStream 1
CAS#:86347-14-0 Medetomidine

HS Code	2942000000

4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride

4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)

1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride

1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

medetomidine HCl

UNII:BH210P244U

4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride

Medetomidine (hydrochloride)

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Medetomidine hydrochloride
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Medetomidine (hydrochloride)
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Medetomidine HCl

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