Medetomidine HCl

Names

[ Name ]:
Medetomidine HCl

[Synonym ]:
4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
medetomidine HCl
UNII:BH210P244U
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride
Medetomidine (hydrochloride)

Biological Activity

[Description]:

Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[References]

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
381.9ºC at 760 mmHg

[ Melting Point ]:
164-166°C

[ Molecular Formula ]:
C₁₃H₁₇ClN₂

[ Molecular Weight ]:
236.740

[ Flash Point ]:
191.3ºC

[ Exact Mass ]:
236.108032

[ PSA ]:
28.68000

[ LogP ]:
3.98030

[ Storage condition ]:
Refrigerator

Safety Information

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000