Metroprolol succinate

Names

[ Name ]:
Metroprolol succinate

[Synonym ]:
UNII:TH25PD4CCB
1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol butanedioate (2:1)
Selozok
1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol butanedioate (2:1) (salt)
Beloc-Zok
Succinic acid - 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol (1:2)
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, butanedioate (2:1) (salt)
Metroprolol succinate
Spesicor Dos
1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol succinate (2:1)
Toprol XL
acide butanedioïque - 1-[4-(2-méthoxyéthyl)phénoxy]-3-[(1-méthyléthyl)amino]propan-2-ol (1:2)
Seloken ZOC
Butandisäure--1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol(1:2)
H 93/26 succinate
Metoprolol (Succinate)

Biological Activity

[Description]:

Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.IC50 value:Target: β1 receptor

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Cardiovascular Disease

[References]

[1]. Benfield P, et al. Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs. 1986 May;31(5):376-429.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
398.6ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₅₆N₂O₁₀

[ Molecular Weight ]:
652.816

[ Flash Point ]:
194.9ºC

[ Exact Mass ]:
652.393494

[ PSA ]:
176.04000

[ LogP ]:
3.94400

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate.

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H370

[ Precautionary Statements ]:
P260

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations.

Eur. J. Pharm. Biopharm. 88(2) , 472-82, (2014)

This study focused on the evaluation of prilling as a technique for the manufacturing of multiparticulate dosage forms. Prills, providing controlled and immediate drug release, were processed and fina...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.