PF-00356231 hydrochloride

Modify Date: 2024-01-17 11:24:30

PF-00356231 hydrochloride structure	Common Name	PF-00356231 hydrochloride
	CAS Number	820223-77-6	Molecular Weight	464.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₁ClN₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PF-00356231 hydrochloride

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

Name	PF-00356231 hydrochloride

Description	PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-12:1.4 μM (IC50) MMP13:0.65 nM (IC50) MMP-3:0.39 μM (IC50) MMP-8:1.7 μM (IC50) MMP-9:0.98 μM (IC50)
In Vitro	PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1].
References	[1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76.

Molecular Formula	C₂₅H₂₁ClN₂O₃S
Molecular Weight	464.96

DC Chemicals Limited
China
Product Name: PF-00356231 hydrochloride
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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PF-00356231 hydrochloride

Use of PF-00356231 hydrochloride

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PF-00356231 hydrochloride Biological Activity

Chemical & Physical Properties