1632250-50-0

1632250-50-0 structure

Name: PF-06446846 hydrochloride
Chemical Name: PF-06446846 hydrochloride
CAS Number: 1632250-50-0
Molecular Formula: C₂₂H₂₀ClN₇O
Molecular Weight: 433.893
Create Date: 2019-09-07 00:01:19
Modify Date: 2025-09-12 15:11:30
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].

Name	PF-06446846 hydrochloride
Synonyms	Benzamide, N-(3-chloro-2-pyridinyl)-N-[(3R)-3-piperidinyl]-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)- N-(3-Chloro-2-pyridinyl)-N-[(3R)-3-piperidinyl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide

Description	PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].
Target	PCSK9[1]
In Vitro	PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM[1].
In Vivo	PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels[1]. Animal Model: Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)[1] Dosage: 5, 15, and 50 mg/kg Administration: Oral gavage; daily for 14 days Result: Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
References	[1]. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.