1632250-49-7
1632250-49-7 structure
- Name: PF-06446846
- Chemical Name: PF-06446846
- CAS Number: 1632250-49-7
- Molecular Formula: C22H20ClN7O
- Molecular Weight: 433.9
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
- Create Date: 2020-01-11 18:21:50
- Modify Date: 2024-01-08 00:57:36
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PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells; shows no general effect on the secreted and intracellular proteome; induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel; reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.
| Name | PF-06446846 |
|---|
| Description | PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells; shows no general effect on the secreted and intracellular proteome; induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel; reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. |
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| References | References 1. Lintner NG, et al. PLoS Biol. 2017 Mar 21;15(3):e2001882. View Related Products by Target PCSK9 |
| Molecular Formula | C22H20ClN7O |
|---|---|
| Molecular Weight | 433.9 |