[DPro4,DTrp7,9] Substance P: 4-11

Modify Date: 2025-09-19 11:37:09

[DPro4,DTrp7,9] Substance P: 4-11 structure	Common Name	[DPro4,DTrp7,9] Substance P: 4-11
	CAS Number	81039-85-2	Molecular Weight	1134.35000
	Density	1.31 g/cm3	Boiling Point	1622.3ºC at 760 mmHg
	Molecular Formula	C₅₇H₇₅N₁₃O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	935ºC

Use of [DPro4,DTrp7,9] Substance P: 4-11

[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].

Name	d-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2
Synonym	More Synonyms

Description	[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
References	[1]. Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. [2]. Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8.

Density	1.31 g/cm3
Boiling Point	1622.3ºC at 760 mmHg
Molecular Formula	C₅₇H₇₅N₁₃O₁₀S
Molecular Weight	1134.35000
Flash Point	935ºC
Exact Mass	1133.55000
PSA	401.88000
LogP	5.80420
Index of Refraction	1.627

CAS#:87572-41-6

[DPro4,DTrp7,9]...

CAS#:81039-85-2

Literature: Caranikas, S.; Mizrahi, J.; Escher, E.; Regoli, D. Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1313 - 1316

H-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2

[DPro4,DTrp7,9] Substance P: 4-11

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[DPro4,DTrp7,9] Substance P: 4-11

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