[DPro4,DTrp7,9] Substance P: 4-11

Modify Date: 2024-02-01 12:04:36

[DPro4,DTrp7,9] Substance P: 4-11 Structure
[DPro4,DTrp7,9] Substance P: 4-11 structure
Common Name [DPro4,DTrp7,9] Substance P: 4-11
CAS Number 81039-85-2 Molecular Weight 1134.35000
Density 1.31 g/cm3 Boiling Point 1622.3ºC at 760 mmHg
Molecular Formula C57H75N13O10S Melting Point N/A
MSDS N/A Flash Point 935ºC

 Use of [DPro4,DTrp7,9] Substance P: 4-11


[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].

 Names

Name d-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2
Synonym More Synonyms

 [DPro4,DTrp7,9] Substance P: 4-11 Biological Activity

Description [D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
Related Catalog
In Vivo [D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
References

[1]. Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5.  

[2]. Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8.  

 Chemical & Physical Properties

Density 1.31 g/cm3
Boiling Point 1622.3ºC at 760 mmHg
Molecular Formula C57H75N13O10S
Molecular Weight 1134.35000
Flash Point 935ºC
Exact Mass 1133.55000
PSA 401.88000
LogP 5.80420
Index of Refraction 1.627

 Synonyms

H-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
[DPro4,DTrp7,9] Substance P: 4-11
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