53749-60-3

53749-60-3 structure

Name: Substance P (4-11)
Chemical Name: Substance P (4-11)/Octa-Substance P
CAS Number: 53749-60-3
Molecular Formula: C₄₆H₆₇N₁₁O₁₀S
Molecular Weight: 966.15700
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-12-26 11:05:52
Modify Date: 2025-08-22 10:38:47
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors[1][2].

Name	Substance P (4-11)/Octa-Substance P
Synonyms	PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 SUBSTANCE P (4-11) L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 substance P fragment 4-11 acetate Substance P,fragment 4-11 OCTA-SUBSTANCE P SUBSTANCE P(4-11),[D-PRO4,D-TRP7,9] Substance-P-(4-11)Octa-Substance P L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 H-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

Description	Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Substance P (4-11) 在浓度为 1 nM-100 nM 时显着刺激体外人 T 淋巴细胞的增殖，通过胸苷和亮氨酸的摄取评估[1]。 Substance P (4-11) 在人多形核白细胞 (PMN) 中引发强烈的学发光，具有时间和剂量反应曲线[3]。
References	[1]. D G Payan, et al. Specific stimulation of human T lymphocytes by substance P. J Immunol. 1983 Oct;131(4):1613-5. [2]. L Wang, et al. Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. Am J Physiol. 1995 Jul;269(1 Pt 1):G85-92. [3]. P Cornaglia-Ferraris, et al. Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine. Int J Immunopharmacol. 1986;8(4):463-8.