6-O-Methyl Guanosine

Modify Date: 2024-01-06 10:22:18

6-O-Methyl Guanosine structure	Common Name	6-O-Methyl Guanosine
	CAS Number	7803-88-5	Molecular Weight	297.267
	Density	2.0±0.1 g/cm3	Boiling Point	721.0±70.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₅N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	389.9±35.7 °C

Use of 6-O-Methyl Guanosine

6-O-Methyl Guanosine is a modified nucleoside[1]. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line[2].

Name	(2R,3S,4R,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonym	More Synonyms

Description	6-O-Methyl Guanosine is a modified nucleoside[1]. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line[2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Inflammation/Immunology
References	[1]. Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50. [2]. Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

Description

6-O-Methyl Guanosine is a modified nucleoside[1]. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line[2].

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Inflammation/Immunology

References

[1]. Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50.

[2]. Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

Density	2.0±0.1 g/cm3
Boiling Point	721.0±70.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₅N₅O₅
Molecular Weight	297.267
Flash Point	389.9±35.7 °C
Exact Mass	297.107330
PSA	148.77000
LogP	-0.58
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.829
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8790000

CHEMICAL NAME :: Guanosine, O-methyl-

CAS REGISTRY NUMBER :: 7803-88-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H15-N5-O5

MOLECULAR WEIGHT :: 297.31

WISWESSER LINE NOTATION :: T56 BN DN FVN INJ HZ B- BT5OTJ CO1 DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2400 nmol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,321,1982

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