Guanosine

Modify Date: 2024-01-02 16:23:58

Guanosine Structure
Guanosine structure
 Common Name Guanosine
CAS Number 118-00-3 Molecular Weight 283.241
Density 2.3±0.1 g/cm3 Boiling Point 756.6±70.0 °C at 760 mmHg
Molecular Formula C10H13N5O5 Melting Point 240ºC
MSDS Chinese USA Flash Point 411.4±35.7 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Guanosine


Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.

 Names

Name guanosine
Synonym More Synonyms

 Guanosine Biological Activity

Description Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP).

 Chemical & Physical Properties

Density 2.3±0.1 g/cm3
Boiling Point 756.6±70.0 °C at 760 mmHg
Melting Point 240ºC
Molecular Formula C10H13N5O5
Molecular Weight 283.241
Flash Point 411.4±35.7 °C
Exact Mass 283.091675
PSA 159.51000
LogP -3.27
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.955
Storage condition 2~8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8750000
CHEMICAL NAME :
Guanosine
CAS REGISTRY NUMBER :
118-00-3
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C10-H13-N5-O5
MOLECULAR WEIGHT :
283.28
WISWESSER LINE NOTATION :
T56 BN DN FMYMVJ GUM D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1 gm/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
750 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
750 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
1 mmol/L
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,52,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9994 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T
Risk Phrases R25
Safety Phrases S24/25
RIDADR UN2811 6.1/PG 3
WGK Germany 3
RTECS MF8750000
Hazard Class 6.1
HS Code 29349990

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
2-Amino-9-(β-D-ribofuranosyl)-3,9-dihydro-6H-purin-6-on
MFCD00010182
2-amino-Inosine
Guanosine
2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one
6H-Purin-6-one, 2-amino-1,9-dihydro-9-β-D-ribofuranosyl-
9-(β-D-Ribofuranosyl)guanine
guanine riboside
Inosine,2-amino
2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one
2-Amino-9-(β-D-ribofuranosyl)-9H-purin-6-ol
EINECS 204-227-8
9-β-D-ribofuranosyl-Guanine
2-Amino-9-(β-D-ribofuranosyl)-1,9-dihydro-6H-purin-6-on
vernine
2H-purin-6-ol, 3,9-dihydro-2-imino-9-β-D-ribofuranosyl-
USAF CB-11
Guanine-9-β-D-ribofuranoside
Guanosin
Guanosine Hydrate
Guanine, 9-β-D-ribofuranosyl-
2-Amino-9-β-D-ribofuranosyl-9H-purine-6(1H)-one
9-β-D-ribofuranosylguanine
9H-purin-6-ol, 2-amino-9-β-D-ribofuranosyl-
2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
Guanozin
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Related Compounds: More...
guanosine
85-30-3
Guanosine
30747-23-0
L-Guanosine
26578-09-6
5'-guanosine
68267-13-0
Azaguanosine
2133-80-4
Guanosine abp
74764-35-5
Guanosine-8-d
96412-41-8
thioguanosine
85-31-4
8-OXOGUANOSINE
3868-31-3
Chemsrc provides Guanosine(CAS#:118-00-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Guanosine are included as well.>> amp version: Guanosine

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