Rimcazole dihydrochloride
Modify Date: 2025-08-25 17:19:09
Rimcazole dihydrochloride structure
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Common Name | Rimcazole dihydrochloride | ||
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| CAS Number | 75859-03-9 | Molecular Weight | 394.38 | |
| Density | N/A | Boiling Point | 499.1ºC at 760 mmHg | |
| Molecular Formula | C21H29Cl2N3 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | 255.7ºC | |
Use of Rimcazole dihydrochlorideRimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can attenuate cocaine-induced locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4]. |
| Name | 9-[3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl]carbazole,dihydrochloride |
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| Synonym | More Synonyms |
| Description | Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can attenuate cocaine-induced locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4]. |
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| Related Catalog | |
| Target |
sigma (σ) receptor[1] dopamine transporter[1] |
| In Vitro | Rimcazole (1-50 μM; 24-48 h) concentration-dependently decreases the number HCT-116p53+/+ cells[2]. Rimcazole (50 μM; 1-24 h) dihydrochloride induces a transient accumulation of HIF-1α protei in cancer cells (HCT-116p53+/+ and MDA MB 231 cells) but not in normal human dermal fibroblasts[2]. Western Blot Analysis[2] Cell Line: HCT-116p53+/+ cells Concentration: 50 μM Incubation Time: 1, 2, 3, 5, 6, 24 hours Result: Accumulation of HIF-1α protein, maximal at 6 h. No change in p53 protein levels. HIF-1α protein levels returned to normal steady-state levels within 24 h. |
| References |
| Boiling Point | 499.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C21H29Cl2N3 |
| Molecular Weight | 394.38 |
| Flash Point | 255.7ºC |
| Exact Mass | 393.17400 |
| PSA | 20.20000 |
| LogP | 5.73750 |
| Hazard Codes | Xi |
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| Rimcazole HCl |
| RIMCAZOLE HYDROCHLORIDE |
| Rimcazole dihydrochloride |