Nolatrexed dihydrochloride

Modify Date: 2024-01-05 15:45:30

Nolatrexed dihydrochloride structure	Common Name	Nolatrexed dihydrochloride
	CAS Number	152946-68-4	Molecular Weight	357.258
	Density	N/A	Boiling Point	493.6ºCat 760 mmHg
	Molecular Formula	C₁₄H₁₄Cl₂N₄OS	Melting Point	301-302ºC
	MSDS	N/A	Flash Point	252.3ºC

Use of Nolatrexed dihydrochloride

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].

Name	2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride
Synonym	More Synonyms

Description	Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Thymidylate Synthase Research Areas >> Cancer
Target	Ki: 11 nM (Human Thymidylate Synthase)[1]
References	[1]. Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17. [2]. McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

Boiling Point	493.6ºCat 760 mmHg
Melting Point	301-302ºC
Molecular Formula	C₁₄H₁₄Cl₂N₄OS
Molecular Weight	357.258
Flash Point	252.3ºC
Exact Mass	356.026550
PSA	109.96000
LogP	4.54510
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Stability	Hygroscopic