Ingenol 3-mebutate
Modify Date: 2024-01-03 09:49:11
Ingenol 3-mebutate structure
|
Common Name | Ingenol 3-mebutate | ||
|---|---|---|---|---|
| CAS Number | 75567-37-2 | Molecular Weight | 430.534 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 576.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H34O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 191.4±23.6 °C | |
Use of Ingenol 3-mebutateIngenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity. |
| Name | ingenol mebutate |
|---|---|
| Synonym | More Synonyms |
| Description | Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity. |
|---|---|
| Related Catalog | |
| Target |
PKC-β:0.105 nM (Ki) PKC-γ:0.162 nM (Ki) PKC-ε:0.171 nM (Ki) PKC-α:0.3 nM (Ki) PKC-δ:0.376 nM (Ki) |
| In Vitro | Ingenol Mebutate (Ingenol 3-angelate) is an active ingredient in Euphorbia peplus, acting as a potent PKC activator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively. Ingenol Mebutate also EC50s of 13 ± 2.4 nM (PKC-α), 4.37 ± 0.4 nM (PKC-βI), 10.5 ± 2.2 nM (PKC-βII), 38.6 ± 2.9 nM (PKC-δ), 1.08 ± 0.01 nM (PKC-ε), 0.9 ± 0.13 nM (PKC-μ) in WEHI-231 cells, 198 ± 12.5 nM (PKC-α), 69.1 ± 8.2 nM (PKC-βI), 4.6 ± 0.4 nM (PKC-ε) and 1 nM (PKC-μ) in HOP-92 cells, 635 ± 245 nM (PKC-α), 146 ± 35 nM (PKC-βI), 4.7 ± 0.7 nM (PKC-δ), 1.1 ± 0.5 nM (PKC-ε), and 30 nM (PKC-μ) in Colo-205 cells. Ingenol Mebutate sensitizes WEHI-231 cells, HOP-92 and Colo-205 cells, with IC50s of 1.41 ± 0.255 nM, 3.24 ± 2.01 nM, and 11.9 ± 1.307 nM, respectively[1]. Ingenol Mebutate (PEP005; 20 nM) actions are PKC-δ dependent, induces apoptosis in primary AML marrow blasts but not in normal myeloblasts[2]. Ingenol Mebutate (PEP005) activates PKCδ and inhibits PKCα. Colo205-R cells (IC50: >10 μM) are >300-fold more resistant to Ingenol Mebutate than parental Colo205-S cells[3]. |
| Cell Assay | KG1a cells are transiently transfected with EGFP-tagged mouse PKC-δ subcloned into pEGFP-N1 plasmid using an Amaxa nucleofection apparatus. Cells are treated with Ingenol Mebutate (0.2 μM-20 μM) 24 hours after transfection. Cell viability in EGFP-positive cells is assessed and loss of viability confirmed in the total cell culture by MTT assay after 3 days. Briefly, 24 hours after transfection, 2 × 104 cells are plated in 5 wells in 96-well plates and exposed to 0, 0.2, 2, and 20 μM Ingenol Mebutate. At 72 hours, 20 μL MTT substrate at 5 mg/mL is added and plates are incubated at 37°C. After 3 hours, 150 μL media is removed and replaced with 200 μL dimethyl sulfoxide (DMSO). Absorbance at an optical density (OD) of 550 nm is read on a plate reader and corrected for absorbance obtained from blank media controls[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.9±50.0 °C at 760 mmHg |
| Molecular Formula | C25H34O6 |
| Molecular Weight | 430.534 |
| Flash Point | 191.4±23.6 °C |
| Exact Mass | 430.235535 |
| PSA | 104.06000 |
| LogP | 5.18 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.594 |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble15mg/mL, clear | Soluble in 100% ethanol, DMSO, dichloromethane, and methanol. Insoluble in water. |
| RIDADR | NONH for all modes of transport |
|---|
CAS#:1356187-24-0
CAS#:1356187-19-3
CAS#:565-63-9
CAS#:77573-43-4
CAS#:30220-46-3
CAS#:94487-74-8
CAS#:1356187-16-0|
RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.
PLoS ONE 8 , e72331, (2013) Ingenol-3-angelate (I3A) is a non-tumor promoting phorbol ester-like compound identified in the sap of Euphoria peplus. Similar to tumor promoting phorbol esters, I3A is a diacylglycerol (DAG) analogu... |
| Indoxyl |A-D-galactopyranoside |
| 3-O-angeloylingenol |
| 2-Butenoic acid, 2-methyl-, (1aR,2R,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)- |
| Ingenol 3-angelate |
| 3-Indolyl-b-D-galactopyranoside |
| (1S,4S,5S,6R,9R,10R,12R,14R)-5,6-Dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0<sup>1,5</sup>.0<sup>10,12</sup>]pentadeca-2,7-dien-4-yl (2Z)-2-methyl-2-butenoate |
| indican (glucoside) |
| Picato |
| Ingenol mebutate |
| (1S,4S,5S,6R,9R,10R,12R,14R)-5,6-Dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0.0]pentadeca-2,7-dien-4-yl (2Z)-2-methyl-2-butenoate |
| Ingenol-3-angelate |
| 3-Ingenyl angelate |
| 3-Angeloylingenol |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ingenol 3-mebutate
- Price: ￥3928.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Ingenol 3-angelate
- Price: $800.0/20mg $1600.0/50mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Ingenol-3-angelate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Ingenol mebutate
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
Get all suppliers and price by the below link:
Price: $222/10mM*1mLinDMSO
Reference only. check more Ingenol 3-mebutate price