466663-11-6

466663-11-6 structure

Name: 3-O-(2'E,4'E-Decadienoyl)-ingenol
Chemical Name: 3-O-(2'E,4'E-Decadienoyl)ingenol
CAS Number: 466663-11-6
Molecular Formula: C₃₀H₄₂O₆
Molecular Weight: 498.651
Catalog: Research Areas Others
Create Date: 2018-11-11 00:49:39
Modify Date: 2024-01-20 11:34:10
3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively[1].

Name	3-O-(2'E,4'E-Decadienoyl)ingenol
Synonyms	2,4-Decadienoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2E,4E)- (1S,4S,5S,6R,9S,10R,12R,14R)-5,6-Dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-4-yl (2E,4E)-2,4-decadienoate

Description	3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	3-O-(2'E,4'E-Decadienoyl)-ingenol（5-30 μg/mL；24 小时）显示出对人类正常细胞系 L-O2 和 GES-1 的细胞毒性，具有剂量依赖关系 [1]。 Cell Cytotoxicity Assay[1] Cell Line: L-O2 and GES-1 cells Concentration: 5 μg/mL, 10 μg/mL,15 μg/mL, 20 μg/mL, 25 μg/mL, 30 μg/mL Incubation Time: 24 hours Result: Showed cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.
References	[1]. Li Zhang, et al. Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int J Mol Sci. 2012;13(9):11247-11259.