Aminopicoline

Modify Date: 2024-01-02 15:55:16

Aminopicoline structure	Common Name	Aminopicoline
	CAS Number	695-34-1	Molecular Weight	108.141
	Density	1.1±0.1 g/cm3	Boiling Point	227.4±20.0 °C at 760 mmHg
	Molecular Formula	C₆H₈N₂	Melting Point	96-99 °C(lit.)
	MSDS	Chinese USA	Flash Point	114.0±9.0 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Aminopicoline

Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS)[1].

Name	4-Methylpyridin-2-amine
Synonym	More Synonyms

Description	Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase
References	[1]. Boer R, et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol. 2000;58(5):1026-1034.

Density	1.1±0.1 g/cm3
Boiling Point	227.4±20.0 °C at 760 mmHg
Melting Point	96-99 °C(lit.)
Molecular Formula	C₆H₈N₂
Molecular Weight	108.141
Flash Point	114.0±9.0 °C
Exact Mass	108.068748
PSA	38.91000
LogP	1.08
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.574
Water Solubility	SOLUBLE

Aminopicoline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ5150000

CHEMICAL NAME :: 4-Picoline, 2-amino-

CAS REGISTRY NUMBER :: 695-34-1

BEILSTEIN REFERENCE NO. :: 0107066

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ BZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,234,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,227S,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H311 + H331-H373
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S53-S45-S60-S61-S37/39-S28A-S26-S36/37/39
RIDADR	UN 3086 6.1/PG 1
WGK Germany	3
RTECS	TJ5150000
Packaging Group	II
Hazard Class	6.1
HS Code	2932999099

2-(2,5-dimethyl...

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Aminopicoline

CAS#:695-34-1

Literature: Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807

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Aminopicoline

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~95%

Aminopicoline

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Salicylic acid

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Literature: Wachi, Kazuyuki; Terada, Atsusuke Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3020 - 3028

4-Picoline

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Aminopicoline

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Literature: Chemische Berichte, , vol. 58, p. 1733 Chemische Berichte, , vol. 58, p. 348 Chemische Berichte, , vol. 57, p. 794

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Aminopicoline

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Literature: Pharmaceutical Chemistry Journal, , vol. 19, # 7 p. 479 - 481 Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 7 p. 829 - 832

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Aminopicoline

CAS#:695-34-1

Literature: Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978

Precursor 5
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DownStream 10
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HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Guide to Receptors and Channels (GRAC), 4th Edition.

Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009)

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

Eur. J. Med. Chem. 44 , 2877-87, (2009)

A series of new 3-aroylpyrido[1,2-a]pyrimidines were synthesized from aryl methyl ketones in a simple two-step procedure and evaluated as nitric oxide synthases (NOS) inhibitors. In order to perform a...

Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle.

Eur. J. Pharmacol. 70(1) , 53-7, (1981)

4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation....

2-amino-4-Me-pyridine

2-Amino-4-meyhylpyrimidine

MFCD00149166

2-Pyridinamine,4-methyl

4-methyl-pyridin-2-ylamine

4-Methyl-2-aminopyridine

2-Amino-4-methylpyridine

2-Amino-4-picoline

2-amino-4-methyl-pyridine

4-Methylpyridin-2-amin

EINECS 234-190-3

Ascensil

4-Methyl-2-pyridylamine

2-Pyridinamine, 4-methyl-

4-PICOLINAMINE

4-PICOLINE,2-AMINO

4-Methyl-2-pyridinamine

4-Methylpyridin-2-amine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Aminopicoline
Price: ￥108.0/100g ￥338.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Aminopicoline
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Amino-4-picoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Aminopicoline

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