Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Aminopicoline
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Aminopicoline
Price: ￥108.0/100g ￥338.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Aminopicoline
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Amino-4-picoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Aminopicoline
Price: ￥Inquiry/1kg ￥Inquiry/25kg ￥Inquiry/200kg
Purity: 99.0%
Stocking Period: 3 Day
Contact: Wang Jie
Email: 3096638339@qq.com

695-34-1

695-34-1 structure

Name: Aminopicoline
Chemical Name: 4-Methylpyridin-2-amine
CAS Number: 695-34-1
Molecular Formula: C₆H₈N₂
Molecular Weight: 108.141
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Methylpyridine
Create Date: 2018-05-22 08:00:00
Modify Date: 2025-08-23 12:02:08
Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS)[1].

Name	4-Methylpyridin-2-amine
Synonyms	2-amino-4-Me-pyridine 2-Amino-4-meyhylpyrimidine MFCD00149166 2-Pyridinamine,4-methyl 4-methyl-pyridin-2-ylamine 4-Methyl-2-aminopyridine 2-Amino-4-methylpyridine 2-Amino-4-picoline 2-amino-4-methyl-pyridine 4-Methylpyridin-2-amin EINECS 234-190-3 Ascensil 4-Methyl-2-pyridylamine 2-Pyridinamine, 4-methyl- 4-PICOLINAMINE 4-PICOLINE,2-AMINO 4-Methyl-2-pyridinamine 4-Methylpyridin-2-amine

Description	Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase
References	[1]. Boer R, et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol. 2000;58(5):1026-1034.

Density	1.1±0.1 g/cm3
Boiling Point	227.4±20.0 °C at 760 mmHg
Melting Point	96-99 °C(lit.)
Molecular Formula	C₆H₈N₂
Molecular Weight	108.141
Flash Point	114.0±9.0 °C
Exact Mass	108.068748
PSA	38.91000
LogP	1.08
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.574
Water Solubility	SOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ5150000

CHEMICAL NAME :: 4-Picoline, 2-amino-

CAS REGISTRY NUMBER :: 695-34-1

BEILSTEIN REFERENCE NO. :: 0107066

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ BZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,234,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,227S,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H311 + H331-H373
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S53-S45-S60-S61-S37/39-S28A-S26-S36/37/39
RIDADR	UN 3086 6.1/PG 1
WGK Germany	3
RTECS	TJ5150000
Packaging Group	II
Hazard Class	6.1
HS Code	2932999099

95337-78-3

~80%

695-34-1

Literature: Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807

1003-67-4

695-34-1

Literature: Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557

76809-23-9

~95%

695-34-1

69-72-7

Literature: Wachi, Kazuyuki; Terada, Atsusuke Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3020 - 3028

108-89-4

695-34-1

Literature: Chemische Berichte, , vol. 58, p. 1733 Chemische Berichte, , vol. 58, p. 348 Chemische Berichte, , vol. 57, p. 794

79917-38-7

695-34-1

Literature: Pharmaceutical Chemistry Journal, , vol. 19, # 7 p. 479 - 481 Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 7 p. 829 - 832

76809-23-9

695-34-1

Literature: Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978

Precursor 5
95337-78-3 1003-67-4 76809-23-9 108-89-4
79917-38-7
DownStream 10
106052-58-8 106218-68-2 3475-21-6 3678-62-4
100848-70-2 54221-95-3 4926-28-7 83004-14-2
550347-54-1 455-69-6

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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