e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

A general and efficient 2-amination of pyridines and quinolines

J Yin, B Xiang, MA Huffman, CE Raab…

Index: Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557

Full Text: HTML

Citation Number: 92

Abstract

... The Journal of Organic Chemistry. ... J. Org. Chem. ... The top aqueous layer was extracted with CH 2 Cl 2 (4 × 10 mL). The combined organic layers were concentrated and chromatographed (SiO 2 , 2 × 20 cm, 1−3% MeOH/CH 2 Cl 2 ) to give 2-aminopyridine (158 mg, 84% yield). ...

4-Phenylpyridine 1-oxide Structure

4-Phenylpyridin...

~%

4-Phenylpyridin-2-amine Structure

4-Phenylpyridin...

Isoquinoline N-oxide Structure

Isoquinoline N-oxide

~%

1-ISOQUINOLINAMINE Structure

1-ISOQUINOLINAMINE

3-methylquinoline n-oxide Structure

3-methylquinoli...

~%

2-AMINO-3-METHYLQUINOLINE Structure

2-AMINO-3-METHY...

4-Methoxypyridine 1-oxide Structure

4-Methoxypyridi...

~%

2-Amino-4-methoxypyridine Structure

2-Amino-4-metho...

quinoline 1-oxide Structure

quinoline 1-oxide

~%

2-Aminoquinoline Structure

2-Aminoquinoline

Picolinic acid N-oxide Structure

Picolinic acid ...

~%

Methyl 6-aminopicolinate Structure

Methyl 6-aminop...

2-Pyridinecarboxylicacid,methylester,1-oxide(9CI) Structure

2-Pyridinecarbo...

~%

Methyl 6-aminopicolinate Structure

Methyl 6-aminop...

3-picoline n-oxide Structure

3-picoline n-oxide

~%

2-Amino-5-methylpyridine Structure

2-Amino-5-methy...

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

4-picoline n-oxide Structure

4-picoline n-oxide

~%

Aminopicoline Structure

3-picoline n-oxide Structure

3-picoline n-oxide

~%

2-Amino-5-methylpyridine Structure

2-Amino-5-methy...

3-Methylpyridin-2-amine Structure

3-Methylpyridin...

Pyridine-4-Carboxylic Acid N-Oxide Structure

Pyridine-4-Carb...

~%

Methyl 2-aMinopyridine-4-carboxylate Structure

Methyl 2-aMinop...

Methyl isonicotinate 1-oxide Structure

Methyl isonicot...

~%

Methyl 2-aMinopyridine-4-carboxylate Structure

Methyl 2-aMinop...

Arylamine based cathepsin K inhibitors: Investigating P3 het...

[Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6807 - 6819]

Design and synthesis of 3, 7-diarylimidazopyridines as inhib...

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 909 - 912]

Studies on 1, 3-benzoxazines. I. Synthesis of primary 2-amin...

[Chemical and Pharmaceutical Bulletin, , vol. 28, # 2 p. 465 - 472]

Design and synthesis of 3, 7-diarylimidazopyridines as inhib...

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 909 - 912]