Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents

T Shinozuka, K Shimada, S Matsui, T Yamane…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6807 - 6819

Full Text: HTML

Citation Number: 9

Abstract

... Bioorganic & Medicinal Chemistry. ... a Medicinal Chemistry Research Laboratories, Sankyo Co ... Cathepsin K is an attractive pharmaceutical target for the treatment of osteoporosis as its primary role is the degradation of type I collagen, one of the main constituents of bone matrix. ...