Hypoxanthine

Modify Date: 2024-01-01 18:46:46

Hypoxanthine Structure
Hypoxanthine structure
 Common Name Hypoxanthine
CAS Number 68-94-0 Molecular Weight 136.111
Density 1.7±0.1 g/cm3 Boiling Point 551.0±30.0 °C at 760 mmHg
Molecular Formula C5H4N4O Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 287.0±24.6 °C

 Use of Hypoxanthine


Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

 Names

Name Hypoxanthine
Synonym More Synonyms

 Hypoxanthine Biological Activity

Description Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1].
In Vivo In pigs, a linear increase of plasma hypoxanthine with duration of hypoxemia is found, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. There is also a direct relationship between survival time and increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62).All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine therefore reflected the prognosis of acute hypoxia in contrast to base deficit[1].
References

[1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 551.0±30.0 °C at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C5H4N4O
Molecular Weight 136.111
Flash Point 287.0±24.6 °C
Exact Mass 136.038513
PSA 74.43000
LogP -0.91
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.816
Storage condition 2-8°C
Water Solubility practically insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0791000
CHEMICAL NAME :
6H-Purin-6-one, 1,7-dihydro-
CAS REGISTRY NUMBER :
68-94-0
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H4-N4-O
MOLECULAR WEIGHT :
136.13
WISWESSER LINE NOTATION :
T56 BN DM FVM INJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
600 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1 gm/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6051 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 541 (estimated) No. of Female Employees: 355 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S22-S24/25-S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UP0791000
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles248

More Articles
Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress.

Microvasc. Res. 98 , 16-22, (2015)

Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter invo...
In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells.

PLoS ONE 10 , e0134768, (2015)

Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the ...
Oxidative stress modulates nucleobase transport in microvascular endothelial cells

Microvasc. Res. 95 , 68-75, (2014)

Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, ...

 Synonyms

3,9-Dihydro-6H-purin-6-on
1,7-Dihydro-6H-purin-6-on
6-Oxopurine
1,7-Dihydro-6H-purin-6-one
7H-Purin-6-ol
PURIN-6-OL
Hypexanthine
SARKIN
SARCINE
Hypoxathine
3,9-Dihydro-6H-purin-6-one
MFCD00005725
Hypoxanthine
Purine-6-ol
6-oxypurine
Sarkine
Hypoxanthin
6-Hydroxypurine
EINECS 200-697-3
1H,7H-Hypoxanthine
1,7-dihydro-purin-6-one
1,7-Dihydro-6H-purine-6-one
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  • Price: ￥Inquiry/20mg
  • Purity: 98.0%
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hypoxanthine
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697807-02-6
Hypoxanthine-d4
2483831-32-7
Hypoxanthine-13C5
2086337-18-8
Hypoxanthine-15N4
77910-30-6
1H,7H-Hypoxanthine
146469-94-5
1H,7H-Hypoxanthine
146469-95-6
1H,7H-Hypoxanthine
51953-23-2
1H,7H-Hypoxanthine
146445-70-7
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