Scrophulein

Modify Date: 2025-08-23 15:08:07

Scrophulein Structure
Scrophulein structure
 Common Name Scrophulein
CAS Number 6601-62-3 Molecular Weight 314.289
Density 1.4±0.1 g/cm3 Boiling Point 563.6±50.0 °C at 760 mmHg
Molecular Formula C17H14O6 Melting Point N/A
MSDS Chinese USA Flash Point 211.5±23.6 °C
Symbol GHS06 GHS09
GHS06, GHS09		 Signal Word Danger

 Use of Scrophulein


Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

 Names

Name cirsimaritin
Synonym More Synonyms

 Scrophulein Biological Activity

Description Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.
Related Catalog
In Vivo Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds[1].
References

[1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 563.6±50.0 °C at 760 mmHg
Molecular Formula C17H14O6
Molecular Weight 314.289
Flash Point 211.5±23.6 °C
Exact Mass 314.079041
PSA 89.13000
LogP 1.97
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.646
InChIKey ZIIAJIWLQUVGHB-UHFFFAOYSA-N
SMILES COc1cc2oc(-c3ccc(O)cc3)cc(=O)c2c(O)c1OC
Storage condition ?20°C

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H410
Precautionary Statements P273-P301 + P310-P501
Hazard Codes T,N
Risk Phrases 25-50
Safety Phrases 45-61
RIDADR UN 2811 6.1 / PGIII
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles13

More Articles
[Studies on flavonoid constituents from herbs of Artemisia ordosica II].

Zhongguo Zhong Yao Za Zhi 31(23) , 1959-61, (2006)

To study the chemical constituents of herbs of Artemisia ordosica.The chemical constituents were isolated and repeatedly purified on silica gel column and the structures were elucidated by the NMR spe...

[Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation].

Zhongguo Zhong Yao Za Zhi 30(17) , 1335-8, (2005)

To study chemical constituents of Incarvillea arguta and their accelerating PC-12 cell differentiation.The constituents were isolated and repeatedly purified on silica gel column chromatography, and w...

[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].

Zhongguo Zhong Yao Za Zhi 30(8) , 591-4, (2005)

To develop a quantitative method for the determination of four flavonoids in buds of Herba Artemisiae Scopariae.The sample was extracted by ultrasonic with ethyl acetate for 30 minutes and separated o...

 Synonyms

5,4'-dihydroxy-6,7-dimethoxyflavone
5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one
Flavone, 4',5-dihydroxy-6,7-dimethoxy-
6,7-Dimethoxyscutellarein
Circimaritin
7-Methylcapillarisin
5-Hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
cirsimartin
5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromen-4-one
Scrophulein
4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy
Skrofulein
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-
4',5-Dihydroxy-6,7-dimethoxyflavone
cirsimaritin
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