Gastrodin

Modify Date: 2024-01-02 09:46:57

Gastrodin structure	Common Name	Gastrodin
	CAS Number	62499-27-8	Molecular Weight	286.278
	Density	1.5±0.1 g/cm3	Boiling Point	563.2±50.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₈O₇	Melting Point	154-157ºC
	MSDS	Chinese USA	Flash Point	294.4±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Gastrodin

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

Name	(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
Synonym	More Synonyms

Description	Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Natural Products >> Phenols
In Vitro	Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].
In Vivo	Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].
Cell Assay	Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].
Animal Admin	Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].
References	[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.

Density	1.5±0.1 g/cm3
Boiling Point	563.2±50.0 °C at 760 mmHg
Melting Point	154-157ºC
Molecular Formula	C₁₃H₁₈O₇
Molecular Weight	286.278
Flash Point	294.4±30.1 °C
Exact Mass	286.105255
PSA	119.61000
LogP	-1.85
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.638

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ5776885

Precursor 9
CAS#:64291-41-4 acetagastrodine CAS#:2280-44-6 D-glucopyranose CAS#:623-05-2 4-Hydroxybenzyl... CAS#:1010838-90-0 (-)-(2R,3S)-1-(...
CAS#:572-09-8 2,3,4,6-Tetra-O... CAS#:78617-45-5 4-(bromomethyl)... CAS#:106-44-5 p-Cresol CAS#:604-69-3 β-D-Glucose pen...
CAS#:14581-78-3 4-methylphenyl ...
DownStream 0

β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Gastrodin Hemihydrate

MFCD00272169

4-(hydroxymethyl)phenyl |A-d-glucopyranoside

Gastrodin

Gastrodin,Gastrodine

S2383_Selleck

4-(Hydroxymethyl)phenyl β-D-glucopyranoside

Gastrodine

BioBioPha
China
Product Name: Gastrodin
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gastrodin
Price: ￥48.0/20mg ￥158.0/5g ￥508.0/25g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Gastrodin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Gastrodin suppliers

Price: ￥108.6/5g

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