Gastrodin

Modify Date: 2019-06-13 17:14:44

Gastrodin Structure
Gastrodin structure
Share to Facebook Share to Twitter Share to Linkedin
Common Name Gastrodin
CAS Number 62499-27-8 Molecular Weight 286.278
Density 1.5±0.1 g/cm3 Boiling Point 563.2±50.0 °C at 760 mmHg
Molecular Formula C13H18O7 Melting Point 154-157ºC
MSDS Chinese USA Flash Point 294.4±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Gastrodin


Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

 Gastrodin Biological Activity

Description Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Related Catalog
In Vitro Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].
In Vivo Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].
Solvent
In Vitro:

10 mM in DMSO

Solubility
1 mM 3.4931 mL 17.4654 mL 34.9308 mL
5 mM 0.6986 mL 3.4931 mL 6.9862 mL
10 mM 0.3493 mL 1.7465 mL 3.4931 mL
Cell Assay Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].
Animal Admin Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2
References

[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.

Related Molecules Captisol | Cyclosporin A | H2DCFDA | MPTP (hydrochloride) | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | Bapta-am | AP20187 | GKT137831 | D-Luciferin | Monocrotaline
Related Doc

SDS |COA |HNMR |LCMS

*The above documents are provided by Medchemexpress and are for scientific research only.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 563.2±50.0 °C at 760 mmHg
Melting Point 154-157ºC
Molecular Formula C13H18O7
Molecular Weight 286.278
Flash Point 294.4±30.1 °C
Exact Mass 286.105255
PSA 119.61000
LogP -1.85
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.638

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LZ5776885

 Synthetic Route

Top Suppliers:I want be here



  • qingyuanshengyi
  • China
  • Product Name: Gastrodin
  • Price: ¥2500.0/1kg ¥1500.0/500g
  • Purity: 99.0%
  • Stocking Period: 1 Day
  • Contact: xiongbei

  • Absin Bioscience Inc
  • China
  • Product Name: Gastrodin
  • Price: ¥200.0/5mg ¥350.0/10mg ¥800.0/50mg
  • Purity: 98.0%
  • Stocking Period: 7 Day
  • Contact: jenny zhou

Get all suppliers and price by the below link:

Gastrodin suppliers


Price: ¥108.6/5g

Reference only. check more Gastrodin price

Hot Compounds More...
Dichloromethane Structure Dichloromethane
CAS#:75-09-2
Polyacrylic acid Structure Polyacrylic acid
CAS#:9003-01-4
sodium carbonate Structure sodium carbonate
CAS#:497-19-8
silicon dioxide Structure silicon dioxide
CAS#:7631-86-9
Triethanolamine Structure Triethanolamine
CAS#:102-71-6
Demeton Structure Demeton
CAS#:126-75-0
Water Structure Water
CAS#:7732-18-5
4-(4-Piperidinyl)morpholine dihydrochloride Structure 4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9
Diclofenac sodium Structure Diclofenac sodium
CAS#:15307-79-6
Budesonide Structure Budesonide
CAS#:51372-29-3