|CAS Number||62499-27-8||Molecular Weight||286.278|
|Density||1.5±0.1 g/cm3||Boiling Point||563.2±50.0 °C at 760 mmHg|
|Molecular Formula||C13H18O7||Melting Point||154-157ºC|
|MSDS||Chinese USA||Flash Point||294.4±30.1 °C|
Use of Gastrodin
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
|Description||Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.|
|In Vitro||Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension.|
|In Vivo||Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively.|
10 mM in DMSO
|Cell Assay||Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).|
|Animal Admin||Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension.|
|Shipping||Room temperature in continental US; may vary elsewhere|
. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.
|Related Molecules||Captisol | Cyclosporin A | H2DCFDA | MPTP (hydrochloride) | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | Bapta-am | AP20187 | GKT137831 | D-Luciferin | Monocrotaline|
*The above documents are provided by Medchemexpress and are for scientific research only.
|Boiling Point||563.2±50.0 °C at 760 mmHg|
|Flash Point||294.4±30.1 °C|
|Vapour Pressure||0.0±1.6 mmHg at 25°C|
|Index of Refraction||1.638|
|Precautionary Statements||P301 + P312 + P330|
|Risk Phrases||R36/37/38:Irritating to eyes, respiratory system and skin .|
|RIDADR||NONH for all modes of transport|