<Suppliers Price>

Gastrodin

Names

[ CAS No. ]:
62499-27-8

[ Name ]:
Gastrodin

[Synonym ]:
β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl
Gastrodin Hemihydrate
MFCD00272169
4-(hydroxymethyl)phenyl |A-d-glucopyranoside
Gastrodin
Gastrodin,Gastrodine
S2383_Selleck
4-(Hydroxymethyl)phenyl β-D-glucopyranoside
Gastrodine

Biological Activity

[Description]:

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Natural Products >> Phenols

[In Vitro]

Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].

[In Vivo]

Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].

[Cell Assay]

Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].

[Animal admin]

Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].

[References]

[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
563.2±50.0 °C at 760 mmHg

[ Melting Point ]:
154-157ºC

[ Molecular Formula ]:
C13H18O7

[ Molecular Weight ]:
286.278

[ Flash Point ]:
294.4±30.1 °C

[ Exact Mass ]:
286.105255

[ PSA ]:
119.61000

[ LogP ]:
-1.85

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.638

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LZ5776885

Synthetic Route

Precursor & DownStream


Related Compounds