4-Hydroxybenzyl alcohol

Names

[ CAS No. ]:
623-05-2

[ Name ]:
4-Hydroxybenzyl alcohol

[Synonym ]:
4-(Hydroxymethyl)benzolol
(4-Hydroxyphenyl)methanol
Gastrodigenin
p-Methylolphenol
4-hydroxymethyl-phenol
PARA-ALCOHOLPHENOL
4-Hydroxybenzyl alcohol
4-hydroxybenzyl-alcohol
Benzyl alcohol, p-hydroxy- (8CI)
p-(Hydroxymethyl)phenol
p-Hydroxybenzyl
4-(Hydroxymethyl)phenol
RARECHEM AL BD 0098
EINECS 210-768-0
Benzenemethanol, 4-hydroxy-
Benzyl alcohol, p-hydroxy-
4-METHYLOLPHENOL
benzyl alcohol, 4-hydroxy-
P-HYDROXYBENZYL ALCOHOL
MFCD00004658
4-HYDROXY-BENZYL-ALCOHOL
α-Hydroxy-p-cresol
FEMA 3987
Bisoprolol Impurity 19

Biological Activity

[Description]:

4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Natural Products >> Phenols

[In Vitro]

4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization[2]. 4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells[3].

[In Vivo]

4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production[1]. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors[3]. 4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway[4].

[References]

[1]. Lim EJ, et al. Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J Pharm Pharmacol. 2007 Sep;59(9):1235-40.

[2]. Laschke MW, et al. In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. Br J Pharmacol. 2011 Jun;163(4):835-44.

[3]. Laschke MW, et al. 4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. Life Sci. 2013 Jul 19;93(1):44-50.

[4]. Yu SS, et al. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res. 2010 Jan 13;1308:167-75.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
252.0±0.0 °C at 760 mmHg

[ Melting Point ]:
114-122 °C(lit.)

[ Molecular Formula ]:
C₇H₈O₂

[ Molecular Weight ]:
124.137

[ Flash Point ]:
145.8±15.0 °C

[ Exact Mass ]:
124.052429

[ PSA ]:
40.46000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.596

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DA4796800

[ HS Code ]:
29072900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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