4-Hydroxybenzyl alcohol

Modify Date: 2024-01-03 17:56:58

4-Hydroxybenzyl alcohol Structure
4-Hydroxybenzyl alcohol structure
 Common Name 4-Hydroxybenzyl alcohol
CAS Number 623-05-2 Molecular Weight 124.137
Density 1.2±0.1 g/cm3 Boiling Point 252.0±0.0 °C at 760 mmHg
Molecular Formula C7H8O2 Melting Point 114-122 °C(lit.)
MSDS Chinese USA Flash Point 145.8±15.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 4-Hydroxybenzyl alcohol


4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].

 Names

Name p-hydroxybenzyl alcohol
Synonym More Synonyms

 4-Hydroxybenzyl alcohol Biological Activity

Description 4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].
Related Catalog
In Vitro 4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization[2]. 4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells[3].
In Vivo 4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production[1]. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors[3]. 4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway[4].
References

[1]. Lim EJ, et al. Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J Pharm Pharmacol. 2007 Sep;59(9):1235-40.

[2]. Laschke MW, et al. In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. Br J Pharmacol. 2011 Jun;163(4):835-44.

[3]. Laschke MW, et al. 4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. Life Sci. 2013 Jul 19;93(1):44-50.

[4]. Yu SS, et al. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res. 2010 Jan 13;1308:167-75.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 252.0±0.0 °C at 760 mmHg
Melting Point 114-122 °C(lit.)
Molecular Formula C7H8O2
Molecular Weight 124.137
Flash Point 145.8±15.0 °C
Exact Mass 124.052429
PSA 40.46000
LogP 0.30
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.596
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DA4796800
HS Code 29072900

 Synthetic Route

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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 Synonyms

4-(Hydroxymethyl)benzolol
(4-Hydroxyphenyl)methanol
Gastrodigenin
p-Methylolphenol
4-hydroxymethyl-phenol
PARA-ALCOHOLPHENOL
4-Hydroxybenzyl alcohol
4-hydroxybenzyl-alcohol
Benzyl alcohol, p-hydroxy- (8CI)
p-(Hydroxymethyl)phenol
p-Hydroxybenzyl
4-(Hydroxymethyl)phenol
RARECHEM AL BD 0098
EINECS 210-768-0
Benzenemethanol, 4-hydroxy-
Benzyl alcohol, p-hydroxy-
4-METHYLOLPHENOL
benzyl alcohol, 4-hydroxy-
P-HYDROXYBENZYL ALCOHOL
MFCD00004658
4-HYDROXY-BENZYL-ALCOHOL
α-Hydroxy-p-cresol
FEMA 3987
Bisoprolol Impurity 19
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3-Bromo-4-hydroxybenzyl alcohol
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3-Amino-4-hydroxybenzyl alcohol
52820-13-0
2-methyl-4-hydroxybenzyl alcohol
10482-16-3
3-Ethoxy-4-hydroxybenzyl alcohol
4912-58-7
2-fluoro-4-hydroxybenzyl alcohol
96740-92-0
3-fluoro-4-hydroxybenzyl alcohol
96740-93-1
2-methyl-4-hydroxybenzyl alcohol
22574-58-9
3-allyloxy-4-hydroxybenzyl alcohol
756525-88-9
3,5-DIBROMO-4-HYDROXYBENZYL ALCOHOL
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