Alaproclate HCl

Modify Date: 2024-01-08 18:25:12

Alaproclate HCl structure	Common Name	Alaproclate HCl
	CAS Number	60719-83-7	Molecular Weight	292.20
	Density	N/A	Boiling Point	324.8ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₉Cl₂NO₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	150.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Alaproclate HCl

Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].

Name	Alaproclate hydrochloride
Synonym	More Synonyms

Description	Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8(1):17574. [2]. Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

References

[1]. Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8(1):17574.

[2]. Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.

Boiling Point	324.8ºC at 760 mmHg
Molecular Formula	C₁₃H₁₉Cl₂NO₂
Molecular Weight	292.20
Flash Point	150.2ºC
Exact Mass	291.07900
PSA	52.32000
LogP	4.05380

Alaproclate HCl MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4397300

CHEMICAL NAME :: DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 60719-83-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H18-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 292.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 901 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22
RIDADR	UN 2811 6.1/PG 3
RTECS	AY4397300

The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.

Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991)

In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cu...

The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.

J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992)

The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chl...

Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.

Psychopharmacology 103(4) , 567-70, (1991)

The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alapro...

[1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-aminopropanoate,hydrochloride

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Product Name: Alaproclate HCl
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