Alaproclate HCl
Names
[ CAS No. ]:
60719-83-7
[ Name ]:
Alaproclate HCl
[Synonym ]:
[1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-aminopropanoate,hydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Boiling Point ]:
324.8ºC at 760 mmHg
[ Molecular Formula ]:
C13H19Cl2NO2
[ Molecular Weight ]:
292.20
[ Flash Point ]:
150.2ºC
[ Exact Mass ]:
291.07900
[ PSA ]:
52.32000
[ LogP ]:
4.05380
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY4397300
- CHEMICAL NAME :
- DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 60719-83-7
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C13-H18-Cl-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 292.23
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 901 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 54 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
20/21/22
[ RIDADR ]:
UN 2811 6.1/PG 3
[ RTECS ]:
AY4397300
Articles
Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991)
In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cu...
The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992)
The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chl...
Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.Psychopharmacology 103(4) , 567-70, (1991)
The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alapro...