Alaproclate HCl
Alaproclate HCl structure
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Common Name | Alaproclate HCl | ||
|---|---|---|---|---|
| CAS Number | 60719-83-7 | Molecular Weight | 292.20 | |
| Density | N/A | Boiling Point | 324.8ºC at 760 mmHg | |
| Molecular Formula | C13H19Cl2NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 150.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.
Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991) In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cued navigation (visible platform) water maze tasks were inve... |
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The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.
J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992) The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chlorophenylalanine (PCPA), a serotonin synthesis inhibitor, (... |
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Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
Psychopharmacology 103(4) , 567-70, (1991) The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alaproclate: 2, 10, 20 mg/kg) on the neocortical electrical activ... |
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Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats.
Psychopharmacology 165(4) , 378-85, (2003) Phencyclidine (PCP) binds with high affinity to a site located within the ionophore of N-methyl- D-aspartate (NMDA) receptors. Previous studies have demonstrated that PCP and other high-affinity NMDA channel blockers reliably disrupt prepulse inhibition (PPI)... |
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Effects of alaproclate, potassium channel blockers, and lidocaine on the release of 3H-acetylcholine from the guinea-pig ileum myenteric plexus.
Pharmacol. Toxicol. 65(1) , 25-32, (1989) The guinea-pig ileum longitudinal muscle-myenteric plexus preparation, preincubated with 3H-choline or 3H-noradrenaline, was mounted in an organ bath and superfused with Tyrode's solution. Alaproclate (2-(4-chlorophenyl)-1,1-dimethyl 2-aminopropanoate) (0.01-... |
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Further studies on the high-affinity binding of 3H-alaproclate to membranes from rat liver and some other tissues.
Pharmacol. Toxicol. 66(3) , 170-5, (1990) The high affinity binding of 3H-alaproclate to membranes in liver homogenates from naive rats and those treated with phenobarbital sodium, 75 mg/kg intraperitoneally, alaproclate hydrochloride, 40 mg/kg intraperitoneally proadifen hydrochloride, 40 mg/kg intr... |
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NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Pharmacol. Toxicol. 80(2) , 97-102, (1997) The effects of alaproclate and GEA-857 (2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate) on the production of cyclic GMP in the rat cerebellum in vivo induced by stimulation of N-methyl-D-aspartate (NMDA) receptors were studied. Alaproclate per... |
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Comparison of high affinity binding of 3H-proadifen and 3H-(-)-cocaine to rat liver membranes.
Pharmacol. Toxicol. 76(2) , 141-5, (1995) The characteristics of the binding of 3H-proadifen to rat liver membranes were studied and compared to those of 3H-cocaine. It was found that 3H-proadifen was bound reversibly with high affinity (KD = 1.8 +/- 0.5 nM) and large capacity (Bmax = 2010 +/- 340 pm... |
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Open space swimming test to index antidepressant activity.
J. Neurosci. Methods 126(1) , 35-40, (2003) Depression is characterized by a lack of "motivation" rather than a lack of "physical space" to move around. This study was designed to evaluate predictivity of an open space swimming test for antidepressant activity of various antidepressants in rats. Withou... |
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Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis?
J. Exp. Biol. 212(Pt 22) , 3728-36, (2009) The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition was investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. Larvae were ... |