Calmidazolium chloride
Calmidazolium chloride structure
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Common Name | Calmidazolium chloride | ||
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| CAS Number | 57265-65-3 | Molecular Weight | 687.698 | |
| Density | N/A | Boiling Point | 724.9ºC at 760mmHg | |
| Molecular Formula | C31H23Cl7N2O | Melting Point | 172-176ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Calmidazolium chlorideCalmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM. |
| Name | Calmidazolium chloride,1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride |
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| Synonym | More Synonyms |
| Description | Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM. |
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| Related Catalog | |
| Target |
Kd: 3 nM (Calmodulin)[3] |
| In Vitro | Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2] Cell Line: Mouse F9 ECCs Concentration: 3, 5, 7, 10 μM Incubation Time: 30 minutes-24 hours Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2]. |
| References |
| Boiling Point | 724.9ºC at 760mmHg |
|---|---|
| Melting Point | 172-176ºC |
| Molecular Formula | C31H23Cl7N2O |
| Molecular Weight | 687.698 |
| Exact Mass | 683.963013 |
| PSA | 18.04000 |
| LogP | 7.29580 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
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| Calmidazolium chloride |
| COMPOUND 48/80 TRIHYDROCHLORIDE |
| 1H-Imidazolium, 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, chloride (1:1) |
| 1-[Bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride |
| COMPOUND 48/80 |
| MFCD00077679 |
| Calimidazoline |
| CALMIDAZOLIUM |