Engeletin

Modify Date: 2024-01-02 17:47:27

Engeletin structure	Common Name	Engeletin
	CAS Number	572-31-6	Molecular Weight	434.39
	Density	1.7±0.1 g/cm3	Boiling Point	820.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₂O₁₀	Melting Point	176-177ºC
	MSDS	N/A	Flash Point	289.5±27.8 °C

Use of Engeletin

Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

Name	Engeletin
Synonym	More Synonyms

Description	Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
Related Catalog	Signaling Pathways >> NF-κB >> NF-κB Research Areas >> Infection Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology
Target	NF-κB
In Vitro	Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation[1].
In Vivo	Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins[1].
Animal Admin	Mice[1] The mice are classified at random into the following six groups of 10 mice each to cause the endometritis model: blank group, LPS group, Engeletin (25, 50, and 100 mg/kg) + LPS groups, and Engeletin (100 mg/kg) group. Engeletin is solubilized by heated normal saline to give the final concentrations of 25, 50, and 100 mg/kg. Briefly, each uterus is infused with 50 μL of LPS (1 mg/mL) to induce endometritis. At 24 h after the instillation, Engeletin groups receive an intraperitoneal injection of diverse Engeletin concentrations (25, 50, and 100 mg/kg) three times (once every 6 h). The Engeletin group is given an intraperitoneal injection of Engeletin (100 mg/kg). The blank group receive the normal saline. Afterward, the mice are killed by CO2 inhalation. Uterus tissues are harvested and kept in −80°C[1].
References	[1]. Wu H, et al. Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation. J Agric Food Chem. 2016 Aug 10;64(31):6171-8.

Density	1.7±0.1 g/cm3
Boiling Point	820.0±65.0 °C at 760 mmHg
Melting Point	176-177ºC
Molecular Formula	C₂₁H₂₂O₁₀
Molecular Weight	434.39
Flash Point	289.5±27.8 °C
PSA	186.37000
LogP	0.25
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.746
Storage condition	2~8℃

Hazard Codes	Xi

Precursor 3
CAS#:572-31-6 Engeletin CAS#:110-86-1 Pyridine CAS#:7732-18-5 Water
DownStream 1
CAS#:572-31-6 Engeletin

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BioBioPha
China
Product Name: Engeletin
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Engeletin
Price: ￥1920.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Engelitin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥660/10 mM * 1 mL in DMSO

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