Pyridine

Pyridine Structure
Pyridine
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Common Name Pyridine
CAS Number 110-86-1 Molecular Weight 79.100
Density 1.0±0.1 g/cm3 Boiling Point 115.3±0.0 °C at 760 mmHg
Molecular Formula C5H5N Melting Point -42 °C
MSDSPyridine MSDS|SDS|pdf download Chinese USA Flash Point 20.0±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Names

[ Name ]: pyridine
[ Synonym ]: More Synonyms

 Chemical & Physical Properties

[ Density ]: 1.0±0.1 g/cm3
[ Boiling Point ]: 115.3±0.0 °C at 760 mmHg
[ Melting Point ]: -42 °C
[ Molecular Formula ]: C5H5N
[ Molecular Weight ]: 79.100
[ Flash Point ]: 20.0±0.0 °C
[ Exact Mass ]: 79.042198
[ PSA ]: 12.89000
[ LogP ]: 0.73
[ Vapour density ]: 2.72 (vs air)
[ Vapour Pressure ]: 22.8±0.2 mmHg at 25°C
[ Index of Refraction ]: 1.501
[ Water Solubility ]: Miscible
[ Freezing Point ]: -42℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UR8400000
CHEMICAL NAME :
Pyridine
CAS REGISTRY NUMBER :
110-86-1
LAST UPDATED :
199806
DATA ITEMS CITED :
64
MOLECULAR FORMULA :
C5-H5-N
MOLECULAR WEIGHT :
79.11
WISWESSER LINE NOTATION :
T6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
891 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - coma
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28500 mg/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
866 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
866 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
880 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1121 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Liver - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - general anesthetic
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - tremor Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
870 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - tremor Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
10 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg/14W-I
TOXIC EFFECTS :
Blood - change in clotting factors Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in adrenal weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mg/m3/24H/60D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
494 mg/kg/5D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,23,1986 *** REVIEWS *** ACGIH TLV-TWA 16 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 4,1,1952 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (15 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,220,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-BELGIUM:TWA 5 ppm (16 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (35 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PYRIDINE-air:10H TWA 5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 65080 No. of Facilities: 1103 (estimated) No. of Industries: 22 No. of Occupations: 18 No. of Employees: 29286 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 65080 No. of Facilities: 1558 (estimated) No. of Industries: 32 No. of Occupations: 42 No. of Employees: 42908 (estimated) No. of Female Employees: 10568 (estimated)

 Safety Information

[ Symbol ]: GHS02 GHS07
GHS02, GHS07
[ Signal Word ]: Danger
[ Hazard Statements ]: H225-H302 + H312 + H332-H315-H319
[ Precautionary Statements ]: P210-P280-P305 + P351 + P338
[ Personal Protective Equipment ]: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]: F:Flammable;Xn:Harmful;
[ Risk Phrases ]: R11;R20/21/22
[ Safety Phrases ]: S36/37/39-S38-S45-S61-S28A-S26-S28-S24/25-S22-S36/37-S16-S7
[ RIDADR ]: UN 1282 3/PG 2
[ WGK Germany ]: 2
[ RTECS ]: UR8400000
[ Packaging Group ]: II
[ Hazard Class ]: 3
[ HS Code ]: 2933990090

 Customs

[ HS Code ]: 2933310010
[ Summary ]: 2933310010 pyridine。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.0%。general tariff:20.0%

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