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572-31-6

572-31-6 structure
572-31-6 structure
  • Name: Engeletin
  • Chemical Name: Engeletin
  • CAS Number: 572-31-6
  • Molecular Formula: C21H22O10
  • Molecular Weight: 434.39
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-08-27 22:41:51
  • Modify Date: 2025-08-26 19:36:28
  • Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
Name Engeletin
Synonyms (2R,3R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-3-yl α-L-mannopyranoside
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(α-L-mannopyranosyloxy)-, (2R,3R)-
Dihydrojuncusol
2,7-Phenanthrenediol,5-ethyl-9,10-dihydro-1,6-dimethyl
Description Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
Related Catalog
Target

NF-κB

In Vitro Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation[1].
In Vivo Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins[1].
Animal Admin Mice[1] The mice are classified at random into the following six groups of 10 mice each to cause the endometritis model: blank group, LPS group, Engeletin (25, 50, and 100 mg/kg) + LPS groups, and Engeletin (100 mg/kg) group. Engeletin is solubilized by heated normal saline to give the final concentrations of 25, 50, and 100 mg/kg. Briefly, each uterus is infused with 50 μL of LPS (1 mg/mL) to induce endometritis. At 24 h after the instillation, Engeletin groups receive an intraperitoneal injection of diverse Engeletin concentrations (25, 50, and 100 mg/kg) three times (once every 6 h). The Engeletin group is given an intraperitoneal injection of Engeletin (100 mg/kg). The blank group receive the normal saline. Afterward, the mice are killed by CO2 inhalation. Uterus tissues are harvested and kept in −80°C[1].
References

[1]. Wu H, et al. Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation. J Agric Food Chem. 2016 Aug 10;64(31):6171-8.
Density 1.7±0.1 g/cm3
Boiling Point 820.0±65.0 °C at 760 mmHg
Melting Point 176-177ºC
Molecular Formula C21H22O10
Molecular Weight 434.39
Flash Point 289.5±27.8 °C
PSA 186.37000
LogP 0.25
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.746
Storage condition 2~8℃
Hazard Codes Xi
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title: CAS No. 572-31-6 | Chemsrc address: https://www.chemsrc.com/en/baike/685143.html

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