Name | Engeletin |
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Synonyms |
(2R,3R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-3-yl α-L-mannopyranoside
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(α-L-mannopyranosyloxy)-, (2R,3R)- Dihydrojuncusol 2,7-Phenanthrenediol,5-ethyl-9,10-dihydro-1,6-dimethyl |
Description | Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects. |
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Related Catalog | |
Target |
NF-κB |
In Vitro | Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation[1]. |
In Vivo | Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins[1]. |
Animal Admin | Mice[1] The mice are classified at random into the following six groups of 10 mice each to cause the endometritis model: blank group, LPS group, Engeletin (25, 50, and 100 mg/kg) + LPS groups, and Engeletin (100 mg/kg) group. Engeletin is solubilized by heated normal saline to give the final concentrations of 25, 50, and 100 mg/kg. Briefly, each uterus is infused with 50 μL of LPS (1 mg/mL) to induce endometritis. At 24 h after the instillation, Engeletin groups receive an intraperitoneal injection of diverse Engeletin concentrations (25, 50, and 100 mg/kg) three times (once every 6 h). The Engeletin group is given an intraperitoneal injection of Engeletin (100 mg/kg). The blank group receive the normal saline. Afterward, the mice are killed by CO2 inhalation. Uterus tissues are harvested and kept in −80°C[1]. |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 820.0±65.0 °C at 760 mmHg |
Melting Point | 176-177ºC |
Molecular Formula | C21H22O10 |
Molecular Weight | 434.39 |
Flash Point | 289.5±27.8 °C |
PSA | 186.37000 |
LogP | 0.25 |
Vapour Pressure | 0.0±3.1 mmHg at 25°C |
Index of Refraction | 1.746 |
Storage condition | 2~8℃ |
Hazard Codes | Xi |
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