Nimustine HCL
Modify Date: 2025-08-21 10:22:04
Nimustine HCL structure
|
Common Name | Nimustine HCL | ||
|---|---|---|---|---|
| CAS Number | 55661-38-6 | Molecular Weight | 309.152 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H14Cl2N6O2 | Melting Point | 186 °C | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Nimustine HCLNimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3]. |
| Name | nimustine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3]. |
|---|---|
| Related Catalog | |
| References |
| Melting Point | 186 °C |
|---|---|
| Molecular Formula | C9H14Cl2N6O2 |
| Molecular Weight | 309.152 |
| Exact Mass | 308.055542 |
| PSA | 113.57000 |
| LogP | 2.57310 |
| InChIKey | KPMKNHGAPDCYLP-UHFFFAOYSA-N |
| SMILES | Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1.Cl |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | R25:Toxic if swallowed. |
| Safety Phrases | S36/37/39-S45 |
| RIDADR | UN 2811 |
| RTECS | YR8450000 |
|
Two new triterpenoid saponins from the aerial parts of Anemone taipaiensis.
J. Asian Nat. Prod. Res. 17 , 576-85, (2015) Phytochemical study on the aerial parts of Anemone taipaiensis for the first time led to the isolation of two new oleanane-type triterpenoid saponins 1 and 2, together with four known saponins (3-6). ... |
|
|
Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines.
J. Vet. Med. Sci. 77 , 677-84, (2015) Canine histiocytic sarcoma (HS) is an aggressive tumor type originating from histiocytic cell lineages. This disease is characterized by poor response to chemotherapy and short survival time. Therefor... |
|
|
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.
Clin. Cancer Res. 16(1) , 99-108, (2010) Hereditary breast cancer is partly explained by germline mutations in BRCA1 and BRCA2. Although patients carry heterozygous mutations, their tumors have typically lost the remaining wild-type allele. ... |
| cs-439 |
| urea, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1) |
| nimustine monohydrochloride |
| 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (1:1) |
| 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1-nitroso-ure |
| Nimustine HCL |
| 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride |
| MFCD01676942 |
| N'-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea hydrochloride |
| 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chlorethyl)-1-nitrosoharnstoffhydrochlorid |
| nimustinaclorhidrato |
| 1-(4-Amino-2-methyl-5-pyrimidinyl)-1-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride |
| 1-((4-amino-2-methyl-5-pyrimidinyl)methyl)-3-(2-chloroethyl)-3-nitrosoure hydrochloride |
| ACNU |
| 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (1:1) |
| Nimustine Hydrochloride |
| nidran |
| 4-amino-5-({[N-(2-chloroethyl)-N-nitrosocarbamoyl]amino}methyl)-2-methylpyrimidin-1-ium chloride |