GMP disodium salt

Modify Date: 2025-08-22 13:50:45

GMP disodium salt structure	Common Name	GMP disodium salt
	CAS Number	5550-12-9	Molecular Weight	407.184
	Density	N/A	Boiling Point	890.2ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₂N₅Na₂O₈P	Melting Point	300°C
	MSDS	USA	Flash Point	492.2ºC

Use of GMP disodium salt

5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].

Name	Guanosine 5'-monophosphate disodium salt
Synonym	More Synonyms

Description	5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].
Related Catalog	Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Lan T, et al. Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation. Biochem Biophys Res Commun. 2019 Aug 6.

Boiling Point	890.2ºC at 760 mmHg
Melting Point	300°C
Molecular Formula	C₁₀H₁₂N₅Na₂O₈P
Molecular Weight	407.184
Flash Point	492.2ºC
Exact Mass	407.021881
PSA	221.51000
Storage condition	2-8°C
Water Solubility	>50 g/L

GMP disodium salt MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF9290000

CHEMICAL NAME :: 5'-Guanylic acid, disodium salt

CAS REGISTRY NUMBER :: 5550-12-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H12-N5-O8-P.2Na

MOLECULAR WEIGHT :: 407.22

WISWESSER LINE NOTATION :: T56 BN DN FN HNVJ GZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >17300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3880 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2720 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5010 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5050 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3580 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1 gm/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1092 No. of Facilities: 177 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1410 (estimated) No. of Female Employees: 33 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MF9290000
HS Code	29349990

Precursor 0
DownStream 2
CAS#:85-32-5 5'-Guanylic acid CAS#:86-01-1 guanosine 5'-(t...

HS Code	29349990

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MFCD00070575

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2'(3')-GMP

GMP

GMP disodium salt

5'-GMP disodium salt

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Na2(5'-GMP)

5'-guanosine monophosphate disodium salt

sodiumgmp

EINECS 226-914-1

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5'-Guanylic acid, sodium salt (1:2)

9H-purin-6-ol, 2-amino-9-(5-O-phosphono-β-D-ribofuranosyl)-, sodium salt (1:2)

5'-GMP 2NA

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FEMA 3668

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