1312992-24-7

1312992-24-7 structure

Name: DNQX disodium salt
Chemical Name: DNQX disodium salt
CAS Number: 1312992-24-7
Molecular Formula: C₈H₂N₄Na₂O₆
Molecular Weight: 296.104
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-05-20 08:00:00
Modify Date: 2024-01-10 10:27:13
DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

Name	DNQX disodium salt
Synonyms	2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-, sodium salt (1:2) Disodium 6,7-dinitro-2,3-quinoxalinediolate Disodium 6,7-dinitroquinoxaline-2,3-diolate

Description	DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	Non-NMDA Receptor[1]
In Vitro	DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].
In Vivo	DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].
References	[1]. Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241(4866):701-703. [2]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103(4):1728-1734. [3]. Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687(1-2):114-124.