NBQX disodium salt
Modify Date: 2025-08-25 13:10:41
NBQX disodium salt structure
|
Common Name | NBQX disodium salt | ||
|---|---|---|---|---|
| CAS Number | 479347-86-9 | Molecular Weight | 380.244 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H6N4Na2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NBQX disodium saltNBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1]. |
| Name | disodium,6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate |
|---|---|
| Synonym | More Synonyms |
| Description | NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1]. |
|---|---|
| Related Catalog | |
| Target |
AMPA receptor[1] |
| In Vitro | NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1]. |
| In Vivo | NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2]. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] Dosage: 20 mg/kg Administration: IP; for 3 days Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |
| References |
| Molecular Formula | C12H6N4Na2O6S |
|---|---|
| Molecular Weight | 380.244 |
| Exact Mass | 379.980347 |
| PSA | 186.26000 |
| LogP | 3.93050 |
| Disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate |
| Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2) |
| FG9202 disodium |
| NBQX disodium |
| FG 9202 disodium salt hydrate |
| NBQX,Disodium Salt |