Kawain structure
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Common Name | Kawain | ||
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CAS Number | 500-64-1 | Molecular Weight | 230.259 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 432.6±45.0 °C at 760 mmHg | |
Molecular Formula | C14H14O3 | Melting Point | 142-148ºC | |
MSDS | N/A | Flash Point | 184.6±23.3 °C |
Use of Kawain(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4]. |
Name | 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (+) |
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Synonym | More Synonyms |
Description | (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4]. |
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Related Catalog | |
Target |
Na+, Ca2+ channel[1]. α4β2δ GABAA receptor[2]. |
In Vitro | (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4]. |
In Vivo | (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 432.6±45.0 °C at 760 mmHg |
Melting Point | 142-148ºC |
Molecular Formula | C14H14O3 |
Molecular Weight | 230.259 |
Flash Point | 184.6±23.3 °C |
Exact Mass | 230.094299 |
PSA | 35.53000 |
LogP | 1.69 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.565 |
Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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HS Code | 2932999099 |
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Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(E)-2-phenylethenyl]-, (6R)- |
4-Methoxy-6-(b-phenylvinyl)-5,6-dihydro-a-pyrone |
4-Methoxy-6-(β-phenylvinyl)-5,6-dihydro-α-pyrone |
(R)-kavain |
5-Hydroxy-3-methoxy-7-phenyl-2,6-heptadienoic Acid d-Lactone |
(+)-kavain |
[R-(E)]-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one |
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (R)- |
Kawain |
Neuronika |
Kavain |
L-KAWAIN |
Gonosan |
(6R)-4-Methoxy-6-[(E)-2-phenylvinyl]-5,6-dihydro-2H-pyran-2-one |
cavain |
5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one |
5,6-Dihydro-4-methoxy-6-styryl-2-pyron |
(R)-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one |
D-Kawain |
4-Methoxy-6-styryl-5,6-dihydro-a-pyrone |
(6R)-4-methoxy-6-[(E)-2-phenylethenyl]-5,6-dihydro-2H-pyran-2-one |