Guvacine

Modify Date: 2025-08-24 08:45:34

Guvacine structure	Common Name	Guvacine
	CAS Number	498-96-4	Molecular Weight	127.141
	Density	1.2±0.1 g/cm3	Boiling Point	280.8±35.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₀ClNO₂	Melting Point	306 - 309 °C(lit.)
	MSDS	N/A	Flash Point	123.6±25.9 °C

Use of Guvacine

Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

Name	guvacine
Synonym	More Synonyms

Description	Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]
References	[1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

Density	1.2±0.1 g/cm3
Boiling Point	280.8±35.0 °C at 760 mmHg
Melting Point	306 - 309 °C(lit.)
Molecular Formula	C₆H₁₀ClNO₂
Molecular Weight	127.141
Flash Point	123.6±25.9 °C
Exact Mass	127.063332
PSA	49.33000
LogP	0.72
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.518

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36

Precursor 9
CAS#:5435-00-7 3-Piperidinecar... CAS#:17210-51-4 Guvacoline Hydr... CAS#:3518-88-5 ethyl 3-(2-etho... CAS#:101599-56-8 3,3'-benzoylimi...
CAS#:495-19-2 guvacoline CAS#:300-08-3 Arecoline hydro... CAS#:121661-86-7 (N-chlorocarbon... CAS#:59-67-6 Nicotinic acid
CAS#:614-18-6 Ethyl nicotinate
DownStream 2
CAS#:498-95-3 Nipecotic acid CAS#:108-99-6 3-Mepy

1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure

1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid

1,2,5,6-tetrahydropyridine-3-carboxylic acid

1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE

3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro

GUVACINE HYDROCHLORIDE

GUVACINE-HCL

1,2,3,6-tetrahydropyridine-5-carboxylic acid

3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-

1,2,5,6-Tetrahydronicotinic acid

Guvacine hydrochloride,1,2,5,6-Tetrahydropyridine-3-carboxylicacidhydrochloride

Guvacine

UNII:41538P325K

MFCD00055191

1,2,5,6-tetrahydro-pyridine-3-carboxylic acid

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Guvacine
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Guvacine
Price: ￥988.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Guvacine hydrochloride
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GUVACINE HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Guvacine suppliers

Price: ￥1500/1 mg

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