Nipecotic acid
Nipecotic acid structure
|
Common Name | Nipecotic acid | ||
|---|---|---|---|---|
| CAS Number | 498-95-3 | Molecular Weight | 129.157 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 265.8±33.0 °C at 760 mmHg | |
| Molecular Formula | C6H11NO2 | Melting Point | 261ºC (dec.) | |
| MSDS | USA | Flash Point | 114.5±25.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Nipecotic acidNipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. |
| Name | nipecotic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
GABA Receptor[1] |
| In Vitro | Nipecotic acid (1 mM) activated inward unitary currents when applied to outside-out patches of paraventricular neurones[1]. |
| In Vivo | Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Melting Point | 261ºC (dec.) |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.157 |
| Flash Point | 114.5±25.4 °C |
| Exact Mass | 129.078979 |
| PSA | 49.33000 |
| LogP | -0.04 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.479 |
| Storage condition | Store at 0-5°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TM6125380 |
| HS Code | 2933399090 |
| Precursor 8 | |
|---|---|
| DownStream 10 | |
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CAS#:89895-55-6| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure–activity relationships
Bioorg. Med. Chem. 18 , 7675-99, (2010) Neuropathic pain is a serious chronic disorder caused by lesion or dysfunction in the nervous systems. Endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioid-rec... |
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Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.
Clin. Chim. Acta 440 , 108-12, (2015) Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders. PA is also a factor responsible for hepatic encephalopathy and a possible biomarker for pyridoxine-de... |
| hexahydronicotinic acid |
| MFCD00005992 |
| (±)-Nipecotic acid |
| (±)-Piperidine-3-carboxylic acid |
| Nipecotic acid |
| UNII:1U1QTN40SY |
| Piperidine-3-carboxylic acid |
| EINECS 207-873-9 |
| (±)-3-Piperidine carboxylic acid |
| 3-Piperidinecarboxylic acid |
| H-DL-Nip-OH |
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- Shanghai Nianxing Industrial Co., Ltd
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