498-95-3

498-95-3 structure

Name: Nipecotic acid
Chemical Name: nipecotic acid
CAS Number: 498-95-3
Molecular Formula: C₆H₁₁NO₂
Molecular Weight: 129.157
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-05-16 08:00:00
Modify Date: 2025-08-20 19:50:38
Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].

Name	nipecotic acid
Synonyms	hexahydronicotinic acid MFCD00005992 (±)-Nipecotic acid (±)-Piperidine-3-carboxylic acid Nipecotic acid UNII:1U1QTN40SY Piperidine-3-carboxylic acid EINECS 207-873-9 (±)-3-Piperidine carboxylic acid 3-Piperidinecarboxylic acid H-DL-Nip-OH

Description	Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABA Receptor[1]
In Vitro	Nipecotic acid (1 mM) activated inward unitary currents when applied to outside-out patches of paraventricular neurones[1].
In Vivo	Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2].
References	[1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TM6125380
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%