6027-92-5
6027-92-5 structure
- Name: Guvacine hydrobromide
- Chemical Name: guvacine hydrobromide
- CAS Number: 6027-92-5
- Molecular Formula: C6H10BrNO2
- Molecular Weight: 208.05
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2017-09-09 23:34:37
- Modify Date: 2024-04-06 12:46:34
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Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].
| Name | guvacine hydrobromide |
|---|---|
| Synonyms |
1,2,5,6-tetrahydro-pyridine-3-carboxylic acid , hydrobromide
1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure, Hydrobromid |
| Description | Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1] |
| References |
| Molecular Formula | C6H10BrNO2 |
|---|---|
| Molecular Weight | 208.05 |
| Exact Mass | 206.98900 |
| PSA | 49.33000 |
| LogP | 1.27760 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
