Juglone

Modify Date: 2025-08-20 12:20:52

Juglone structure	Common Name	Juglone
	CAS Number	481-39-0	Molecular Weight	174.153
	Density	1.4±0.1 g/cm3	Boiling Point	385.8±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₆O₃	Melting Point	161-163 °C(lit.)
	MSDS	Chinese USA	Flash Point	201.3±24.4 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of Juglone

Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1].

Name	juglone
Synonym	More Synonyms

Description	Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. J. Johnson Inbaraj, et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004, 17, 1, 55-62

Density	1.4±0.1 g/cm3
Boiling Point	385.8±42.0 °C at 760 mmHg
Melting Point	161-163 °C(lit.)
Molecular Formula	C₁₀H₆O₃
Molecular Weight	174.153
Flash Point	201.3±24.4 °C
Exact Mass	174.031693
PSA	54.37000
LogP	1.86
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.662
Storage condition	Refrigerator (+4°C)
Water Solubility	SOLUBLE IN HOT WATER

Juglone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5775000

CHEMICAL NAME :: 1,4-Naphthalenedione, 5-hydroxy-

CAS REGISTRY NUMBER :: 481-39-0

BEILSTEIN REFERENCE NO. :: 1909764

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H6-O3

MOLECULAR WEIGHT :: 174.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 394 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 10 mg/kg

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335-H400
Precautionary Statements	P261-P273-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S22-S26-S36/37/39-S45-S37/39-S28A
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	QJ5775000
Packaging Group	III
Hazard Class	6.1
HS Code	2914690090

Precursor 7
CAS#:83-56-7 1,5-Dihydroxyna... CAS#:496-64-0 3-Hydroxy-2H-Py... CAS#:106-51-4 1,4-Benzoquinone CAS#:569-42-6 1,8-Naphthalenediol
CAS#:5196-28-1 5-(acetyloxy)-1... CAS#:115031-12-4 2-Morpholinomet... CAS#:481-40-3 naphthalene-1,4...
DownStream 10
CAS#:481-72-1 Aloeemodin CAS#:477-85-0 Obtusifolin CAS#:481-74-3 Chrysophanic acid CAS#:67116-22-7 8-hydroxy-1-met...
CAS#:18855-92-0 2-chloro-8-hydr... CAS#:18713-45-6 (8-acetyloxy-3-... CAS#:481-42-5 Plumbagin CAS#:14777-17-4 5-hydroxy-3-met...
CAS#:80596-51-6 2,3-dimethyl-5-... CAS#:129-43-1 1-HYDROXYANTHRA...

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.

Oncotarget 6 , 16488-506, (2015)

Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor su...

Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III.

J. Enzyme Inhib. Med. Chem. 30 , 420-9, (2015)

An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid an...

Determination of the Juglone Content of Juglans regia Leaves by GC/MS.

Nat. Prod. Commun. 10 , 1239-42, (2015)

The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic ext...

Nucin

Juglone

EINECS 207-567-5

5-Hydroxy-1,4-naphthalenedione

C.I. Natural Brown 7

5-hydroxynaphthalene-1,4-dione

Regianin

CI 75500

5-hydroxy-1,4-dihydronaphthalene-1,4-dione

5-Hydroxy-1,4-naphthochinone

1,4-Naphthalenedione, 5-hydroxy-

5-HNQ

5-Hydroxy-p-naphthoquinone

MFCD00001684

5-Hydroxy-1,4-naphthoquinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Juglone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Juglone
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Juglone
Price: ￥398.0/20mg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 5-Hydroxy-1,4-naphthalenedione(Juglone)
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥500/5 mg

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Juglone

Use of Juglone

Names

Juglone Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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Synonyms

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