Obtusifolin structure
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Common Name | Obtusifolin | ||
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CAS Number | 477-85-0 | Molecular Weight | 284.263 | |
Density | 1.448±0.06 g/cm3 | Boiling Point | 528.0±50.0 °C at 760 mmHg | |
Molecular Formula | C16H12O5 | Melting Point | 242-243ºC | |
MSDS | N/A | Flash Point | 202.2±23.6 °C |
Use of ObtusifolinObtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
Name | 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione |
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Synonym | More Synonyms |
Description | Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
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Related Catalog | |
Target |
NF-κB |
In Vitro | Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1]. |
References |
Density | 1.448±0.06 g/cm3 |
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Boiling Point | 528.0±50.0 °C at 760 mmHg |
Melting Point | 242-243ºC |
Molecular Formula | C16H12O5 |
Molecular Weight | 284.263 |
Flash Point | 202.2±23.6 °C |
Exact Mass | 284.068481 |
PSA | 83.83000 |
LogP | 4.18 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.678 |
Storage condition | -20℃ |
Water Solubility | Insuluble (2.6E-3 g/L) (25 ºC) |
~0% Obtusifolin CAS#:477-85-0 |
Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
~98% Obtusifolin CAS#:477-85-0 |
Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
~60% Obtusifolin CAS#:477-85-0 |
Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
~% Obtusifolin CAS#:477-85-0 |
Literature: Krohn, Carsten; Khanbabaee, Karamali Liebigs Annalen der Chemie, 1993 , # 8 p. 905 - 910 |
Precursor 7 | |
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DownStream 2 | |
Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl |
2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone |
Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl- |
9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl- |
2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon |
obtusifoline |
Obtusifolin (anthraquinone) |
1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone |
2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone |
Obtusifolin |
2,8-dihydroxy-1-methoxy-3-methylanhraquinone |
2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione |