Obtusifolin

Names

[ CAS No. ]:
477-85-0

[ Name ]:
Obtusifolin

[Synonym ]:
Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl
2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone
Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl-
9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl-
2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon
obtusifoline
Obtusifolin (anthraquinone)
1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone
2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone
Obtusifolin
2,8-dihydroxy-1-methoxy-3-methylanhraquinone
2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione

Biological Activity

[Description]:

Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

NF-κB

[In Vitro]

Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1].

[References]

[1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928.

[2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40.

Chemical & Physical Properties

[ Density]:
1.448±0.06 g/cm3

[ Boiling Point ]:
528.0±50.0 °C at 760 mmHg

[ Melting Point ]:
242-243ºC

[ Molecular Formula ]:
C₁₆H₁₂O₅

[ Molecular Weight ]:
284.263

[ Flash Point ]:
202.2±23.6 °C

[ Exact Mass ]:
284.068481

[ PSA ]:
83.83000

[ LogP ]:
4.18

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.678

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Insuluble (2.6E-3 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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