1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Modify Date: 2025-08-21 20:47:20

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane structure	Common Name	1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
	CAS Number	470-67-7	Molecular Weight	154.249
	Density	1.0±0.1 g/cm3	Boiling Point	173.5±8.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	−46 °C(lit.)
	MSDS	Chinese USA	Flash Point	50.7±15.3 °C
	Symbol	GHS02	Signal Word	Warning

Use of 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Name	1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
Synonym	More Synonyms

Description	1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6. [2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Description

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

References

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Density	1.0±0.1 g/cm3
Boiling Point	173.5±8.0 °C at 760 mmHg
Melting Point	−46 °C(lit.)
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	50.7±15.3 °C
Exact Mass	154.135757
PSA	9.23000
LogP	2.58
Vapour Pressure	1.7±0.3 mmHg at 25°C
Index of Refraction	1.491
Storage condition	-20℃

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS9274000

CHEMICAL NAME :: p-Menthane, 1,4-epoxy-

CAS REGISTRY NUMBER :: 470-67-7

BEILSTEIN REFERENCE NO. :: 0104974

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)

Symbol	GHS02
Signal Word	Warning
Hazard Statements	H226
Precautionary Statements	P210-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Risk Phrases	R10
Safety Phrases	S16
RIDADR	UN 1993 3/PG 3
WGK Germany	2
RTECS	OS9274000
Packaging Group	III
Hazard Class	3.2

Precursor 9
CAS#:99-86-5 alpha-Terpinene CAS#:470-82-6 Cineole CAS#:562-74-3 Terpinine-4-ol CAS#:512-85-6 Ascaridole
CAS#:78-79-5 isoprene CAS#:565-48-0 (Z)-terpin CAS#:7664-93-9 Sulfuric acid CAS#:98-55-5 Terpineol
CAS#:7664-38-2 Phosphoric acid
DownStream 1
CAS#:562-74-3 Terpinine-4-ol

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.

Mol. Pain 8 , 86, (2012)

Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanism...

[Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].

Zhong Yao Cai 33(3) , 385-7, (2010)

To analyze the chemical constituents of the essential oil from Chimonanthus zhejiangensis.Steam distillation was employed to extract volatile compounds of essential oil from Chimonanthus zhejiangensis...

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Isocineole

1,4-Cineole (natural)

MFCD00209502

1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane

1-(2-methylethyl)-4-methyl-7-oxabicyclo[2.2.1]heptane

1,4-EPOXY-P-MENTHANE

1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane

7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-

1,4-Cineol

1,4-Cineole

FEMA No. 3658

p-Menthane,1,4-epoxy

EINECS 207-428-9

p-Menthane, 1,4-epoxy

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Price: Check
Purity: 85.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Price: ￥1108.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,4-Cineole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1,4-Cineole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane suppliers

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane price

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Use of 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Names

Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles10

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.