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470-67-7

470-67-7 structure
470-67-7 structure

Name 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
Synonyms 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Isocineole
1,4-Cineole (natural)
MFCD00209502
1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane
1-(2-methylethyl)-4-methyl-7-oxabicyclo[2.2.1]heptane
1,4-EPOXY-P-MENTHANE
1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane
7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
1,4-Cineol
1,4-Cineole
FEMA No. 3658
p-Menthane,1,4-epoxy
EINECS 207-428-9
p-Menthane, 1,4-epoxy
Description 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].
Related Catalog
References

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Density 1.0±0.1 g/cm3
Boiling Point 173.5±8.0 °C at 760 mmHg
Melting Point −46 °C(lit.)
Molecular Formula C10H18O
Molecular Weight 154.249
Flash Point 50.7±15.3 °C
Exact Mass 154.135757
PSA 9.23000
LogP 2.58
Vapour Pressure 1.7±0.3 mmHg at 25°C
Index of Refraction 1.491
Storage condition -20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OS9274000
CHEMICAL NAME :
p-Menthane, 1,4-epoxy-
CAS REGISTRY NUMBER :
470-67-7
BEILSTEIN REFERENCE NO. :
0104974
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)
Symbol GHS02
GHS02
Signal Word Warning
Hazard Statements H226
Precautionary Statements P210-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Risk Phrases R10
Safety Phrases S16
RIDADR UN 1993 3/PG 3
WGK Germany 2
RTECS OS9274000
Packaging Group III
Hazard Class 3.2