Terpinine-4-ol

Modify Date: 2025-08-20 20:32:51

Terpinine-4-ol structure	Common Name	Terpinine-4-ol
	CAS Number	562-74-3	Molecular Weight	154.249
	Density	0.9±0.1 g/cm3	Boiling Point	209.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	79.4±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Terpinine-4-ol

Terpinen-4-ol (4-Carvomenthenol), a naturally occurring monoterpene, is the main bioactive component of tea-tree oil. Terpinen-4-ol suppresses inflammatory mediator production by activated human monocytes. Terpinen-4-ol significantly enhances the effect of several chemotherapeutic and biological agents[1][2][3].

Name	4-terpineol
Synonym	More Synonyms

Description	Terpinen-4-ol (4-Carvomenthenol), a naturally occurring monoterpene, is the main bioactive component of tea-tree oil. Terpinen-4-ol suppresses inflammatory mediator production by activated human monocytes. Terpinen-4-ol significantly enhances the effect of several chemotherapeutic and biological agents[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Hart PH, et al. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm Res. 2000 Nov;49(11):619-26. [2]. Shapira S, et al. Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PLoS One. 2016 Jun 8;11(6):e0156540.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. Hart PH, et al. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm Res. 2000 Nov;49(11):619-26.

[2]. Shapira S, et al. Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PLoS One. 2016 Jun 8;11(6):e0156540.

Density	0.9±0.1 g/cm3
Boiling Point	209.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	79.4±0.0 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.99
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.485
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	Very slightly soluble

Terpinine-4-ol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OT0175110

CHEMICAL NAME :: para-Menth-1-en-4-ol

CAS REGISTRY NUMBER :: 562-74-3

BEILSTEIN REFERENCE NO. :: 1906603

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1016 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CCHCDE Zhonghua Jiehe He Huxixi Jibing Zazhi. Chinese Journal of Tuberculosis and Respiratory Diseases. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1978- Volume(issue)/page/year: 4(4),203,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2137 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1167 (estimated) No. of Female Employees: 51 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S37/39
WGK Germany	2
RTECS	OT0175110

Precursor 8
CAS#:105273-31-2 (Z)-3,7-dimethy... CAS#:470-67-7 1-Isopropyl-4-m... CAS#:138-86-3 limonene CAS#:4584-23-0 2,2,6-trimethyl...
CAS#:763-10-0 GERANYL PYROPHO... CAS#:25570-95-0 1,4-dichloro-tr... CAS#:2009-00-9 (+)-sabinene CAS#:27621-71-2 1,4-dichloro-p-...
DownStream 6
CAS#:470-67-7 1-Isopropyl-4-m... CAS#:586-62-9 Terpinolene CAS#:99-86-5 alpha-Terpinene CAS#:99-85-4 γ-terpinene
CAS#:586-63-0 isoterpinolene CAS#:4821-04-9 4-terpinenyl acetate

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).

Fitoterapia 100 , 95-109, (2015)

In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Is...

Fumigant toxicity and acetylcholinesterase inhibitory activity of 4 Asteraceae plant essential oils and their constituents against Japanese termite (Reticulitermes speratus Kolbe).

Pestic. Biochem. Physiol. 113 , 55-61, (2014)

This study investigated the fumigant toxicity of 4 Asteraceae plant essential oils and their constituents against the Japanese termite Reticulitermes speratus Kolbe. Fumigant toxicity varied with plan...

3-Cyclohexen-1-ol, 4-methyl-1- (1-methylethyl)-

EINECS 209-235-5

1-Isopropyl-4-methyl-3-cyclohexen-1-ol

4-methyl-1-[1-methylethyl]-3-cyclohexen-1-ol

4-terpineol

4-terpinenol

terpineol-4

Terpine-4-ol

Terpene-4-ol

Terpinenol-4

p-menth-1-en-4-ol

(±)-4-Terpineol

Terpin-4-ol

1-(1-Methylethyl)-4-methyl-3-cyclohexen-1-ol

(±)-Terpinen-4-ol

Terpinen-4-ol

Terpinenolu-4

3-Cyclohexen-1-ol, 4-methyl-1-(1-methylethyl)-

dl-4-Terpineol

4-Methyl-1-(1-methylethyl)-3-cyclohexene-1-ol

FEMA 2248

1-Isopropyl-4-methylcyclohex-3-en-1-ol

MFCD00001562

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Terpinine-4-ol
Price: Check
Purity: 98.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Terpinine-4-ol
Price: ￥Inquiry/1mg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Terpinen-4-ol
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Terpinen-4-ol
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Terpinen-4-ol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM -Terpinen-4-ol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Terpinine-4-ol

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MSDS

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