limonene

limonene Structure
limonene
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Common Name limonene
CAS Number 138-86-3 Molecular Weight 136.234
Density 0.8±0.1 g/cm3 Boiling Point 175.4±20.0 °C at 760 mmHg
Molecular Formula C10H16 Melting Point -84--104 °C
MSDS Chinese USA Flash Point 42.8±0.0 °C
Symbol GHS02 GHS07 GHS09
GHS02, GHS07, GHS09
Signal Word Warning

 Use of limonene


Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities[1]. Anti-proliferative activities[2]. Antioxidant and anti-inflammatory effect[3].

 Names

Name limonene
Synonym More Synonyms

 limonene Biological Activity

Description Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities[1]. Anti-proliferative activities[2]. Antioxidant and anti-inflammatory effect[3].
Related Catalog
Target

Bacterial[1]

In Vitro Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound[1]. Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability[2].
In Vivo Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression[3].
Solvent
In Vitro:

10 mM in DMSO

Solubility
1 mM 7.3405 mL 36.7026 mL 73.4053 mL
5 mM 1.4681 mL 7.3405 mL 14.6811 mL
10 mM 0.7341 mL 3.6703 mL 7.3405 mL
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping Room temperature in continental US; may vary elsewhere
SMILES C=C(C1CC=C(C)CC1)C
References

[1]. Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6.

[2]. Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44.

[3]. de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.

Related Molecules Puromycin dihydrochloride | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

 Chemical & Physical Properties

Density 0.8±0.1 g/cm3
Boiling Point 175.4±20.0 °C at 760 mmHg
Melting Point -84--104 °C
Molecular Formula C10H16
Molecular Weight 136.234
Flash Point 42.8±0.0 °C
Exact Mass 136.125198
LogP 4.45
Vapour density 4.7 (vs air)
Vapour Pressure 1.5±0.2 mmHg at 25°C
Index of Refraction 1.468
Stability Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility <1 g/100mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OS8100000
CHEMICAL NAME :
p-Mentha-1,8-diene
CAS REGISTRY NUMBER :
138-86-3
LAST UPDATED :
199712
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C10-H16
MOLECULAR WEIGHT :
136.26
WISWESSER LINE NOTATION :
L6UTJ A1 DY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5550 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1010 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
4600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987- Volume(issue)/page/year: 113,47,1990 *** REVIEWS *** TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1342 No. of Facilities: 3959 (estimated) No. of Industries: 70 No. of Occupations: 60 No. of Employees: 45463 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1342 No. of Facilities: 12642 (estimated) No. of Industries: 103 No. of Occupations: 90 No. of Employees: 185336 (estimated) No. of Female Employees: 45650 (estimated)

 Safety Information

Symbol GHS02 GHS07 GHS09
GHS02, GHS07, GHS09
Signal Word Warning
Hazard Statements H226-H315-H317-H410
Precautionary Statements P273-P280-P501
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases R10;R38;R43;R50/53
Safety Phrases S24-S37-S60-S61
RIDADR UN 2052 3/PG 3
WGK Germany 2
RTECS OS8350000
Packaging Group III
Hazard Class 3
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2942000000

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