(-)-Borneol

Modify Date: 2024-01-02 22:01:47

(-)-Borneol structure	Common Name	(-)-Borneol
	CAS Number	464-45-9	Molecular Weight	154.249
	Density	1.0±0.1 g/cm3	Boiling Point	212.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	206-209 °C
	MSDS	Chinese USA	Flash Point	65.6±0.0 °C
	Symbol	GHS02, GHS07	Signal Word	Warning

Use of (-)-Borneol

(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

Name	(-)-borneol
Synonym	More Synonyms

Description	(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides
Target	EC50: 237 μM (GABA receptor)[1]
In Vitro	(-)-Borneol is an enantiomer of (+)-Borneol. (+)-Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. At high concentrations (>1.5 mM), (-)-Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (-)-Borneol produces dose-dependent positive modulation of the Cl- conductance generated by extremely low dose GABA at α1β2γ2L GABAA receptors[1].
References	[1]. IGranger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11.

Density	1.0±0.1 g/cm3
Boiling Point	212.0±0.0 °C at 760 mmHg
Melting Point	206-209 °C
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	65.6±0.0 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.71
Vapour density	5.31 (vs air)
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.502
Water Solubility	INSOLUBLE

(-)-Borneol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DT5095000

CHEMICAL NAME :: Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)-

CAS REGISTRY NUMBER :: 464-45-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

WISWESSER LINE NOTATION :: L55 ATJ A1 A1 B1 CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978

Symbol	GHS02, GHS07
Signal Word	Warning
Hazard Statements	H228-H317
Precautionary Statements	P210-P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	F:Flammable;
Risk Phrases	R11
Safety Phrases	S16-S36/37
RIDADR	UN 1312 4.1/PG 3
WGK Germany	2
RTECS	DT5095000
Packaging Group	III
Hazard Class	4.1
HS Code	29061900

Precursor 5
CAS#:100703-54-6 [2(R)-(1-bornyl... CAS#:54384-77-9 (1S,2R,4S)-2-((... CAS#:100703-55-7 2(S)-(1-bornylo... CAS#:100837-41-0 2(S)-(1-bornylo...
CAS#:100703-52-4 2(R)-(1-bornylo...
DownStream 10
CAS#:560-09-8 (-)-Camphoric acid CAS#:79-92-5 (+)-Camphene CAS#:4443-48-5 3-bromo-4,7,7-t... CAS#:4501-58-0 α-campholenaldehyde
CAS#:464-48-2 (±)-Camphor CAS#:93-53-8 2-Phenylpropion... CAS#:81115-69-7 (-)-2-bornanyl ... CAS#:81115-66-4 (S)-(-)-2-pheny...
CAS#:20279-31-6 (1,7,7-trimethy... CAS#:20279-25-8 Borneol, propionate

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Kinetics and mechanisms of the tropospheric reactions of menthol, borneol, fenchol, camphor, and fenchone with hydroxyl radicals (OH) and chlorine atoms (Cl).

J. Phys. Chem. A 116(16) , 4097-107, (2012)

Relative kinetic techniques have been used to measure the rate coefficients for the reactions of oxygenated terpenes (menthol, borneol, fenchol, camphor, and fenchone) and cyclohexanol with hydroxyl r...

Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats.

Microcirculation 20(1) , 17-29, (2013)

The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.Sprague-Dawley rats were subjected to 30 minutes occlusion of the LADCA, fo...

Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells.

Pharm. Biol. 51(1) , 30-5, (2013)

The β-amyloid (Aβ) peptide aggregation with accompanying oxidative stress plays the major role in the pathogenesis of Alzheimer's disease (AD). Some natural compounds, including borneol, shed promisin...

L-BORNEOL

l-2-Bornanol

Borneol

endo-(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol

endo-2-hydroxycamphane

2-Camphanol

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)-

L(-)-Borneol

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)-

(1S,2R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol

[(1s)-endo]-(-)-borneol

2-Bornanol, endo-

EINECS 207-353-1

(1S-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol

(-)-Borneol

(−)-Borneol

Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)-

FEMA 2157

(1S)-endo-(-)-Borneol

BICYCLO(2.2.1)HEPTAN-2-OL, 1,7,7-TRIMETHYL-, (1S-ENDO)-

2-bornanol

Bornan-2-ol

MFCD00003759

(？)-Borneol

endo-2-Bornanol

Linderol

endo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, endo-

endo-2-camphanol

ngaicamphor

bornel

BioBioPha
China
Product Name: (-)-Borneol
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (-)-Borneol
Price: ￥478.0/5mg ￥178.0/25g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (-)-Borneol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (-)-borneol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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(-)-Borneol

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(-)-Borneol Biological Activity

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